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肠道细菌在肝细胞癌发生发展中的潜在作用。

Potential role of gut bacteria in the development of hepatocellular carcinoma.

作者信息

Yan Bingqing, Wang Yuchao, Wang Ziqi, Huang Ailong, Jin Xiuxiu, Jiang Tiantian, Xue Hong, Shen Zheyu, Wang Shifang, Xu Haiyan, Zhu Renfei

机构信息

Nantong Center for Disease Control and Prevention, Nantong, PR China.

Nantong Third People's Hospital, Nantong, PR China.

出版信息

Access Microbiol. 2025 Aug 21;7(8). doi: 10.1099/acmi.0.000859.v6. eCollection 2025.

Abstract

Liver cancer is the fourth most deadly cancer, and early detection and timely treatment apparently play a crucial role in it. Intestinal bacteria affect the development of liver cancer through various pathways. In this study, the gut bacteria of liver cancer patients are analysed in detail by using metagenomic sequencing technology, and some of the bacterial species and metabolic pathways that may affect the development of liver cancer have been identified. Additionally, we identified bacterial factors that may impact key clinical indicators of the tumour. The findings of this study provide a scientific foundation for understanding the mechanisms underlying liver cancer development. This study freshened insights into clinical treatment strategies for liver cancer.

摘要

肝癌是第四大致命癌症,早期检测和及时治疗显然在其中起着关键作用。肠道细菌通过多种途径影响肝癌的发展。在本研究中,利用宏基因组测序技术对肝癌患者的肠道细菌进行了详细分析,已确定了一些可能影响肝癌发展的细菌种类和代谢途径。此外,我们还确定了可能影响肿瘤关键临床指标的细菌因素。本研究结果为理解肝癌发生的潜在机制提供了科学依据。这项研究为肝癌的临床治疗策略提供了新的见解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a017/12369552/6fbb749d1a82/acmi-7-00859-g001.jpg

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