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研究人员的信任与参与阿尔茨海默病生物标志物研究意愿之间的关联。

Association between Trust of Researchers and Willingness to Participate in Alzheimer's Disease Biomarker Research.

作者信息

Raelly-Muze Laureen, Etchison Taylor, Crouch Adele, Eliacin Johanne, Polsinelli Angelina, Gao Sujuan, Van Heiden Sarah, Asper Joseph, Elliott Caprice, Richards Ralph, Richards Mollie, Campbell Christopher, Hendrie Hugh, Shaw Pamella, Adeoye-Olatunde Omolola, Risacher Shannon, Saykin Andrew, Wang Sophia

机构信息

University of Texas Health San Antonio, 7703 Floyd Curl Dr San Antonio, Texas, 78229 USA.

Indiana Alzheimer's Disease Research Center, 355 W. 16th Street Indianapolis, Indiana, 46202 USA.

出版信息

Alzheimers Dement Behav Socioecon Aging. 2025 Sep;1(3). doi: 10.1002/bsa3.70024. Epub 2025 Jul 1.

DOI:10.1002/bsa3.70024
PMID:40852489
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12369659/
Abstract

INTRODUCTION: The study examined the relationship between trust of researchers in research naïve participants, including those at higher risk, and interest in Alzheimer's disease and related dementia (ADRD) biomarker research participation. METHODS: A cohort of 399 community-dwelling older adults completed a survey about their trust of researchers and interest in participating in ADRD biomarker research. RESULTS: After controlling for sociodemographics and knowledge of ADRD, higher trust of researchers was associated with lower levels of hesitancy to participate in ADRD biomarker and neuroimaging studies ( < 0.001). Higher trust of researchers was associated with agreement with research-related motivation statements and interest in return of results from neuroimaging and memory tests ( < 0.05). DISCUSSION: Our findings show that trust of researchers is highly correlated with research participation, independent of knowledge of ADRD and sociodemographics, and should be a focus to accelerate ADRD biomarker research participation, such as groups at higher risk.

摘要

引言：该研究考察了研究新手参与者（包括那些风险较高的参与者）对研究人员的信任与对阿尔茨海默病及相关痴呆症（ADRD）生物标志物研究参与的兴趣之间的关系。 方法：一组399名居住在社区的老年人完成了一项关于他们对研究人员的信任以及参与ADRD生物标志物研究的兴趣的调查。 结果：在控制了社会人口统计学因素和ADRD知识后，对研究人员的更高信任与参与ADRD生物标志物和神经影像学研究的较低犹豫程度相关（<0.001）。对研究人员的更高信任与对与研究相关动机陈述的认同以及对神经影像学和记忆测试结果反馈的兴趣相关（<0.05）。 讨论：我们的研究结果表明，对研究人员的信任与研究参与高度相关，独立于ADRD知识和社会人口统计学因素，并且应该成为加速ADRD生物标志物研究参与的重点，例如风险较高的群体。

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Association between Trust of Researchers and Willingness to Participate in Alzheimer's Disease Biomarker Research.

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本文引用的文献

[1]
Developing and applying potentially scalable recruitment strategies to accelerate ADRD research participation of Black adults.

Alzheimers Dement. 2025-2

[2]
The Alzheimer's Disease Neuroimaging Initiative-4 (ADNI-4) Engagement Core: A culturally informed, community-engaged research (CI-CER) model to advance brain health equity.

Alzheimers Dement. 2024-12

[3]
Variations in racial and ethnic groups' trust in researchers associated with willingness to participate in research.

Humanit Soc Sci Commun. 2023

[4]
"I Want to Know Everything ...  ": The Return of Research Results and the Importance of Transparency in the Acceptability of Lumbar Punctures for African American Older Adults.

J Alzheimers Dis. 2023

[5]
Age-Specific Barriers and Facilitators to Research Participation Amongst African Americans in Observational Studies of Memory and Aging.

J Racial Ethn Health Disparities. 2024-10

[6]
Quantification of race/ethnicity representation in Alzheimer's disease neuroimaging research in the USA: a systematic review.

Commun Med (Lond). 2023-7-25

[7]
Barriers and facilitators to participating in Alzheimer's disease biomarker research in black and white older adults.

Alzheimers Dement (N Y). 2023-6-5

[8]
Development and Validation of the Perceptions of Research Trustworthiness Scale to Measure Trust Among Minoritized Racial and Ethnic Groups in Biomedical Research in the US.

JAMA Netw Open. 2022-12-1

[9]
Recruitment of Older African Americans in Alzheimer's Disease Clinical Trials Using a Community Education Approach.

J Prev Alzheimers Dis. 2022

[10]
Listening to Voices from African American Communities in the Southern States about COVID-19 Vaccine Information and Communication: A Qualitative Study.

Vaccines (Basel). 2022-6-29

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