Raelly-Muze Laureen, Etchison Taylor, Crouch Adele, Eliacin Johanne, Polsinelli Angelina, Gao Sujuan, Van Heiden Sarah, Asper Joseph, Elliott Caprice, Richards Ralph, Richards Mollie, Campbell Christopher, Hendrie Hugh, Shaw Pamella, Adeoye-Olatunde Omolola, Risacher Shannon, Saykin Andrew, Wang Sophia
University of Texas Health San Antonio, 7703 Floyd Curl Dr San Antonio, Texas, 78229 USA.
Indiana Alzheimer's Disease Research Center, 355 W. 16th Street Indianapolis, Indiana, 46202 USA.
Alzheimers Dement Behav Socioecon Aging. 2025 Sep;1(3). doi: 10.1002/bsa3.70024. Epub 2025 Jul 1.
The study examined the relationship between trust of researchers in research naïve participants, including those at higher risk, and interest in Alzheimer's disease and related dementia (ADRD) biomarker research participation.
A cohort of 399 community-dwelling older adults completed a survey about their trust of researchers and interest in participating in ADRD biomarker research.
After controlling for sociodemographics and knowledge of ADRD, higher trust of researchers was associated with lower levels of hesitancy to participate in ADRD biomarker and neuroimaging studies ( < 0.001). Higher trust of researchers was associated with agreement with research-related motivation statements and interest in return of results from neuroimaging and memory tests ( < 0.05).
Our findings show that trust of researchers is highly correlated with research participation, independent of knowledge of ADRD and sociodemographics, and should be a focus to accelerate ADRD biomarker research participation, such as groups at higher risk.
该研究考察了研究新手参与者（包括那些风险较高的参与者）对研究人员的信任与对阿尔茨海默病及相关痴呆症（ADRD）生物标志物研究参与的兴趣之间的关系。
一组399名居住在社区的老年人完成了一项关于他们对研究人员的信任以及参与ADRD生物标志物研究的兴趣的调查。
在控制了社会人口统计学因素和ADRD知识后，对研究人员的更高信任与参与ADRD生物标志物和神经影像学研究的较低犹豫程度相关（<0.001）。对研究人员的更高信任与对与研究相关动机陈述的认同以及对神经影像学和记忆测试结果反馈的兴趣相关（<0.05）。
我们的研究结果表明，对研究人员的信任与研究参与高度相关，独立于ADRD知识和社会人口统计学因素，并且应该成为加速ADRD生物标志物研究参与的重点，例如风险较高的群体。
