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老年人术后认知功能障碍的发生率:一项使用基于网络的蒙特利尔认知评估应用程序的前瞻性队列研究。

Incidence of postoperative cognitive dysfunction in older adults: a prospective cohort study using a web-based Montreal cognitive assessment application.

作者信息

Pongraweewan Panithi, Tornsatitkul Surapa, Siriussawakul Arunotai, Krishnamoorthy Vijay, Sangarunakul Nipaporn, Jiraphorncharas Chalita, Hemrungrojn Solaphat, Nupairoj Natawut

机构信息

Department of Anesthesiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Integrated Perioperative Geriatric Excellent Research Center, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.

出版信息

Sci Rep. 2025 Aug 25;15(1):31180. doi: 10.1038/s41598-025-15961-2.

Abstract

Thailand is transitioning into a super-aged society, and its growing elderly population faces an increased risk of postoperative cognitive dysfunction (POCD). Despite its association with reduced quality of life and heightened mortality, POCD remains underdiagnosed. This study aimed to evaluate the incidence of POCD using a web-based Montreal Cognitive Assessment application (Auto-MoCA) at 1 week postoperatively. We also compared characteristics between patients with and without POCD and examined recovery patterns at 3 months. We conducted a prospective, descriptive cohort study at a university hospital in Bangkok, enrolling Thai-speaking patients aged ≥ 60 years who underwent major elective surgery. Cognitive function was repeatedly assessed via the Auto-MoCA application at baseline, 1 week, and 3 months. POCD was defined as a decrease of ≥ 2 points from baseline. Among 169 enrolled patients, 111 completed the 1-week assessment. POCD occurred in 40.5%, with significant declines in visuospatial, attention, language, abstraction, and orientation domains. Cardiovascular disease was a significant risk factor. By 3 months, 85 patients repeated the Auto-MoCA test. Of these, 34 (40.0%) had developed POCD compared to their baseline results, with 42.9% of affected patients recovered, primarily demonstrating improvements in visuospatial, attention, and delayed recall domains. Postoperative cognitive dysfunction (POCD) was common in older adults, affecting over 40% of patients at both 1 week and 3 months after surgery. With Cardiovascular disease emerged as a significant risk factor. However, nearly half of those affected showed cognitive recovery by 3 months. Underscoring the utility of digital cognitive assessment tools, such as the Auto-MoCA application, and highlight the need for future interventional research aiming to facilitate cognitive recovery in older adults following surgery.

摘要

泰国正在步入超老龄化社会,其不断增长的老年人口面临术后认知功能障碍(POCD)风险增加的问题。尽管POCD与生活质量下降和死亡率升高有关,但仍未得到充分诊断。本研究旨在使用基于网络的蒙特利尔认知评估应用程序(自动MoCA)评估术后1周时POCD的发生率。我们还比较了有POCD和无POCD患者的特征,并检查了3个月时的恢复模式。我们在曼谷的一家大学医院进行了一项前瞻性描述性队列研究,纳入年龄≥60岁、讲泰语且接受大型择期手术的患者。通过自动MoCA应用程序在基线、1周和3个月时反复评估认知功能。POCD定义为较基线下降≥2分。在169名登记患者中,111名完成了1周评估。POCD发生率为40.5%,视觉空间、注意力、语言、抽象和定向领域有显著下降。心血管疾病是一个重要的危险因素。到3个月时,85名患者重复了自动MoCA测试。其中,34名(40.0%)与基线结果相比出现了POCD,42.9%的受影响患者恢复了,主要表现为视觉空间、注意力和延迟回忆领域的改善。术后认知功能障碍(POCD)在老年人中很常见,在术后1周和3个月时影响超过40%的患者。心血管疾病是一个重要的危险因素。然而,近一半的受影响患者在3个月时显示出认知恢复。强调了数字认知评估工具(如自动MoCA应用程序)的实用性,并突出了未来旨在促进老年人术后认知恢复的干预性研究的必要性。

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