Rabiei Manoochehr, Albaruni Md Abu Sina Ibne, Joshi Vatsal, Cho Michael, Bowling Alan
Department of Mechanical and Aerospace Engineering, University of Texas at Arlington, 701 S Nedderman Dr, Arlington, 76019, TX, USA.
Department of Bioengineering, University of Texas at Arlington, 701 S Nedderman Dr, Arlington, 76019, TX, USA.
Multibody Syst Dyn. 2024 Dec 11. doi: 10.1007/s11044-024-10044-y.
This paper presents a high-speed, long-term approach to simulating the mechanobiology of cells with an inhomogeneous mass distribution ranging from femtograms to picograms. An accurate representation of cellular processes necessitates the inclusion of subcellular structures characterized by minute masses and dimensions. The minute objects yield multiscale dynamic models with disproportionate terms, which require inordinate amounts of computational time to simulate. The computational requirements limit the time span of the simulation to time histories shorter than one second, even when employing supercomputers. This paper examines adipogenesis, the transformation of human bone marrow-derived mesenchymal stem cells (hMSC) into adipocytes, a process that spans two weeks. The proposed simulation techniques are based on a novel scaling technique that addresses differently sized masses. This work addresses unique challenges beyond the authors' earlier work, which addressed disproportionality between large stiffness and damping forces in relation to small masses in the dynamic model. This new approach reduces computational time to less than 1 hour and 45 minutes on a standard desktop computer for the two-week duration of adipogenesis.
本文提出了一种高速、长期的方法，用于模拟质量分布不均匀（从飞克到皮克）的细胞的力学生物学。准确表示细胞过程需要纳入以微小质量和尺寸为特征的亚细胞结构。这些微小物体产生具有不成比例项的多尺度动态模型，模拟这些模型需要大量的计算时间。即使使用超级计算机，计算需求也将模拟的时间跨度限制为短于一秒的时间历程。本文研究了脂肪生成，即人类骨髓间充质干细胞（hMSC）向脂肪细胞的转化过程，该过程持续两周。所提出的模拟技术基于一种解决不同大小质量问题的新型缩放技术。这项工作解决了作者早期工作之外的独特挑战，早期工作解决了动态模型中与小质量相关的大刚度和阻尼力之间的不成比例问题。这种新方法在标准台式计算机上，对于为期两周的脂肪生成过程，将计算时间减少到不到1小时45分钟。
