标志物在软组织肿瘤诊断中的应用。

Application of markers in the diagnosis of soft tissue tumours.

作者信息

Roholl P J, De Jong A S, Ramaekers F C

出版信息

Histopathology. 1985 Oct;9(10):1019-35. doi: 10.1111/j.1365-2559.1985.tb02782.x.

DOI:10.1111/j.1365-2559.1985.tb02782.x

Abstract

In this review we describe the application of markers which are useful for the diagnosis of soft tissue tumours in paraffin sections. Detection of intermediate filament proteins appears to be most useful for first screening of these neoplasms because all, except neuroblastomas, express vimentin; cytokeratin is expressed in synovial sarcomas, epithelioid sarcomas and mesotheliomas; desmin in myogenic tumours and glial fibrillary acidic protein in astrocytomas and gliomas. Tissue-specific markers are: factor VIII--related antigen-endothelial cells; myoglobulin and skeletal muscle myosin--skeletal muscle cells; neuron specific enolase--neurons and cells of the APUD systems; and leukocyte-associated antigen--leukocytes. Markers which are present in a variety of cell types and therefore do not serve as tissue-specific markers are; S-100 proteins, alpha-1-antichymotrypsin, creatine kinase M and actin. The S-100 antigens have been detected in melanomas, granular cell tumours, chondrosarcomas and in some schwannomas and liposarcomas. Alpha-1-antichymotrypsin has been found in fibrohistiocytic and 'true' histiocytic tumours and creatine kinase M and actin in myogenic tumours. No specific markers have, as yet, been described for fibrosarcomas, Ewing's sarcomas and hemangiopericytomas.

摘要

在本综述中，我们描述了有助于石蜡切片中软组织肿瘤诊断的标志物的应用。检测中间丝蛋白似乎对这些肿瘤的初步筛查最为有用，因为除神经母细胞瘤外，所有肿瘤均表达波形蛋白；细胞角蛋白在滑膜肉瘤、上皮样肉瘤和间皮瘤中表达；结蛋白在肌源性肿瘤中表达，胶质纤维酸性蛋白在星形细胞瘤和神经胶质瘤中表达。组织特异性标志物有：因子VIII相关抗原——内皮细胞；肌红蛋白和骨骼肌肌球蛋白——骨骼肌细胞；神经元特异性烯醇化酶——神经元和APUD系统的细胞；以及白细胞相关抗原——白细胞。存在于多种细胞类型中、因此不作为组织特异性标志物的标志物有：S-100蛋白、α1抗糜蛋白酶、肌酸激酶M和肌动蛋白。S-100抗原已在黑色素瘤、颗粒细胞瘤、软骨肉瘤以及一些神经鞘瘤和脂肪肉瘤中检测到。α1抗糜蛋白酶在纤维组织细胞性和“真性”组织细胞性肿瘤中被发现，肌酸激酶M和肌动蛋白在肌源性肿瘤中被发现。目前尚未描述纤维肉瘤、尤因肉瘤和血管外皮细胞瘤的特异性标志物。