Paz Concepción, Suárez Eduardo, Gil Christian, Rivadulla Casto
CINTECX, Universidade de Vigo, Campus Universitario Lagoas-Marcosende, 36310, Vigo, Spain.
Biofluids Research Group, Galicia Sur Health Research Institute (IIS Galicia Sur), SERGAS-UVIGO, Vigo, Spain.
Sci Rep. 2025 Aug 27;15(1):31575. doi: 10.1038/s41598-025-15362-5.
Transcranial static magnetic stimulation has shown the capacity to decrease systematically the cortical excitability in the treatment of epilepsy. Nevertheless, the application of these therapies to non-focal epilepsies is limited. This paper investigates on the numerical evaluation of promising strategies based on the application of static magnetic fields with multiple magnets on children. Results show that a ten-magnet configuration on the child's head generates a magnetic flux density of 0.10 T in more than 70% of the brain cortex and more than 0.05 T in deep areas near the brain's base. Conversely, the interaction between individual magnetic fields leads to regions of lower flux density, suggesting that not only the number of magnets, but also their relative position and orientation, are critical parameters. Thus, based on image diagnosis, it is possible to define a personalising procedure and develop an effective therapy of global epilepsy that penetrates sufficiently into the brain´s volume.
经颅静磁刺激已显示出在癫痫治疗中系统性降低皮质兴奋性的能力。然而，这些疗法在非局灶性癫痫中的应用有限。本文研究了基于在儿童头部应用多个磁体的有前景策略的数值评估。结果表明，在儿童头部采用十磁体配置时，超过70%的大脑皮层会产生0.10 T的磁通密度，在靠近脑底部的深部区域会产生超过0.05 T的磁通密度。相反，各个磁场之间的相互作用会导致磁通密度较低的区域，这表明不仅磁体数量，而且它们的相对位置和方向都是关键参数。因此，基于图像诊断，可以定义一种个性化程序，并开发一种能充分渗透到脑容积中的全身性癫痫有效疗法。
