预防性抗生素使用时长对新生儿外科手术部位感染率的影响：一项多中心回顾性观察研究
Impact of prophylactic antibiotic duration on surgical site infection rate in neonatal surgery: a multicenter retrospective observational study.
作者信息
Sunouchi Tomohiro, Fujishiro Jun, Oba Koji, Ishimaru Tetsuya, Ogimi Chikara, Kawashima Hiroshi, Nishi Akira, Maruyama Kenichi, Tanaka Kiyoshi, Takayasu Hajime, Tanaka Yujiro, Obana Kazuko, Yoneda Ryu, Ishiguro Akio, Matsuyama Yutaka
机构信息
Department of Pediatric Surgery, The University of Tokyo Hospital, Tokyo, Japan.
Department of Biostatistics, School of Public Health, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
出版信息
J Perinatol. 2025 Aug 27. doi: 10.1038/s41372-025-02400-3.
OBJECTIVE
To evaluate the relationship between the incidence of surgical site infections (SSIs) and the duration of perioperative antibiotic prophylaxis (PAP) in neonatal surgery, and to identify risk factors for SSIs in neonates.
METHODS
Eligible patients were neonates who underwent surgical procedures-primarily in the respiratory and gastrointestinal fields-between January 2014 and December 2023 at seven institutions. All data were retrospectively retrieved from electronic patient records. We estimated the risk difference using a modified least-squares regression model.
RESULTS
Of the 983 patients included, 91 (9%) developed SSIs. A total of 735 patients (75%) received PAP for >24 h. There was no significant difference in risk when PAP duration was <24 h compared with ≥24 h. Independent risk factors for SSIs were an operative time exceeding 120 min, past surgical history, and open surgery.
CONCLUSION
In neonatal surgery, a short duration (<24 h) of PAP may not increase the risk of SSI.
目的
评估新生儿手术中手术部位感染（SSIs）的发生率与围手术期抗生素预防（PAP）持续时间之间的关系，并确定新生儿SSIs的危险因素。
方法
符合条件的患者为2014年1月至2023年12月期间在七家机构接受主要涉及呼吸和胃肠道领域手术的新生儿。所有数据均从电子病历中回顾性获取。我们使用改良的最小二乘回归模型估计风险差异。
结果
在纳入的983例患者中，91例（9%）发生了SSIs。共有735例患者（75%）接受PAP超过24小时。PAP持续时间<24小时与≥24小时相比，风险无显著差异。SSIs的独立危险因素是手术时间超过120分钟、既往手术史和开放手术。
结论
在新生儿手术中，短时间（<24小时）的PAP可能不会增加SSIs的风险。
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