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颅内动脉瘤破裂:治疗的总体效果以及患者选择和数据呈现对报告结果的影响。

Ruptured intracranial aneurysms: the overall effect of treatment and the influence of patient selection and data presentation on the reported outcome.

作者信息

Maurice-Williams R S, Marsh H

出版信息

J Neurol Neurosurg Psychiatry. 1985 Dec;48(12):1208-12. doi: 10.1136/jnnp.48.12.1208.

Abstract

An attempt is made to assess the overall impact of current treatment of ruptured intracranial aneurysms, based on the outcome in 200 consecutive patients, unselected in that they were transferred to neurosurgical care as soon as they were referred, regardless of clinical condition. Overall mortality at 1 year was 35.5%. It is estimated that at the present time treatment improves the one-year survival of patients who reach the primary care hospital by no more than 12-15%. In assessing the apparent benefits of treatment, it is easy to overlook the effects of patient selection and the way in which data are presented. Other admission policies in line with current practice but involving greater selectivity and delay in transfer, could have reduced the one-year mortality of this series of patients to 16.1%, by excluding from neurosurgical care patients who were in a poor condition or about to deteriorate. The outcome data in this series could be presented in different ways so as to represent the surgical mortality as ranging between 13.8% and 3.3%.

摘要

基于200例连续患者的治疗结果,对当前颅内破裂动脉瘤治疗的总体影响进行评估。这些患者未经过筛选,一经转诊即被转至神经外科治疗,无论其临床状况如何。1年时的总死亡率为35.5%。据估计,目前的治疗方法使到达基层医院的患者1年生存率提高不超过12% - 15%。在评估治疗的明显益处时,很容易忽略患者选择的影响以及数据呈现的方式。按照当前做法但采用更具选择性且转诊延迟的其他收治政策,通过将病情不佳或即将恶化的患者排除在神经外科治疗之外,本系列患者的1年死亡率可能会降至16.1%。本系列的结果数据可以用不同方式呈现,以使手术死亡率在13.8%至3.3%之间。

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