• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

治疗雄激素性脱发的透皮给药系统进展

Advances in Transdermal Delivery Systems for Treating Androgenetic Alopecia.

作者信息

Xu Shilong, Zhou Lian, Zhao Haodong, Li Siwen

机构信息

State Key Laboratory of Natural Medicines, Department of Biomedical Engineering, School of Engineering, China Pharmaceutical University, No. 639 Longmian Avenue, Jiangning District, Nanjing 211198, China.

NMPA Key Laboratory for Impurity Profile of Chemical Drugs, Jiangsu Institute for Drug Control, Nanjing 210019, China.

出版信息

Pharmaceutics. 2025 Jul 30;17(8):984. doi: 10.3390/pharmaceutics17080984.

DOI:10.3390/pharmaceutics17080984
PMID:40871007
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12389719/
Abstract

Androgenetic alopecia (AGA) is the most prevalent form of alopecia areata. Traditional treatment options, including minoxidil, finasteride, and hair transplantation, have their limitations, such as skin irritation, systemic side effects, invasiveness, and high costs. The transdermal drug delivery system (TDDS) offers an innovative approach for treating AGA by administering medications through the skin to achieve localized and efficient delivery while overcoming the skin barrier. This review systematically explores the application of TDDS in AGA treatment, highlighting emerging technologies such as microneedles (MNs), liposomes, ionic liquids (ILs), nanostructured lipid carriers (NLCs), and transporters (TFs). It analyzes the underlying mechanisms that enhance drug penetration through hair follicles. Finally, this review presents a forward-looking perspective on the future use of TDDS in the management of AGA, aiming to provide insights and references for designing effective transdermal drug delivery systems for this condition.

摘要

雄激素性脱发（AGA）是斑秃最常见的形式。传统的治疗方法，包括米诺地尔、非那雄胺和毛发移植，都有其局限性，如皮肤刺激、全身副作用、侵入性和高成本。经皮给药系统（TDDS）通过皮肤给药来治疗AGA，提供了一种创新方法，以实现局部高效给药，同时克服皮肤屏障。本文系统地探讨了TDDS在AGA治疗中的应用，重点介绍了微针（MNs）、脂质体、离子液体（ILs）、纳米结构脂质载体（NLCs）和转运体（TFs）等新兴技术。分析了增强药物通过毛囊渗透的潜在机制。最后，本文对TDDS在AGA管理中的未来应用提出了前瞻性观点，旨在为设计针对这种情况的有效经皮给药系统提供见解和参考。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b71/12389719/dd581b82f060/pharmaceutics-17-00984-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b71/12389719/8d6d516bcf3f/pharmaceutics-17-00984-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b71/12389719/d178d79643c1/pharmaceutics-17-00984-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b71/12389719/d3f6ed24fdbd/pharmaceutics-17-00984-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b71/12389719/c3f27f77f99b/pharmaceutics-17-00984-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b71/12389719/3dfa3c220536/pharmaceutics-17-00984-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b71/12389719/0fb2cdfb4df9/pharmaceutics-17-00984-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b71/12389719/dbdadb78f238/pharmaceutics-17-00984-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b71/12389719/fad1de727263/pharmaceutics-17-00984-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b71/12389719/dd581b82f060/pharmaceutics-17-00984-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b71/12389719/8d6d516bcf3f/pharmaceutics-17-00984-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b71/12389719/d178d79643c1/pharmaceutics-17-00984-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b71/12389719/d3f6ed24fdbd/pharmaceutics-17-00984-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b71/12389719/c3f27f77f99b/pharmaceutics-17-00984-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b71/12389719/3dfa3c220536/pharmaceutics-17-00984-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b71/12389719/0fb2cdfb4df9/pharmaceutics-17-00984-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b71/12389719/dbdadb78f238/pharmaceutics-17-00984-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b71/12389719/fad1de727263/pharmaceutics-17-00984-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b71/12389719/dd581b82f060/pharmaceutics-17-00984-g009.jpg

相似文献

1
Advances in Transdermal Delivery Systems for Treating Androgenetic Alopecia.治疗雄激素性脱发的透皮给药系统进展
Pharmaceutics. 2025 Jul 30;17(8):984. doi: 10.3390/pharmaceutics17080984.
2
Optimizing efficacy: Hyaluronic acid liposomes encapsulating minoxidil for enhanced transdermal delivery and treatment of androgenetic alopecia.优化疗效：包封米诺地尔的透明质酸脂质体用于增强透皮给药及治疗雄激素性脱发
Colloids Surf B Biointerfaces. 2025 Jul 16;255:114956. doi: 10.1016/j.colsurfb.2025.114956.
3
Prescription of Controlled Substances: Benefits and Risks管制药品的处方：益处与风险
4
Microenvironment-responsive recombinant collagen XVII-based composite microneedles for the treatment of androgenetic alopecia.用于治疗雄激素性脱发的微环境响应性重组 XVII 型胶原基复合微针
Acta Biomater. 2025 Jun 15;200:400-415. doi: 10.1016/j.actbio.2025.05.039. Epub 2025 May 17.
5
Robust Metformin Nanosystem Promotes Hair Growth in Androgenetic Alopecia.强效二甲双胍纳米系统促进雄激素性脱发的头发生长。
Research (Wash D C). 2025 Jul 18;8:0780. doi: 10.34133/research.0780. eCollection 2025.
6
A Prospective Study of Exosome Therapy for Androgenetic Alopecia.外泌体疗法治疗雄激素性脱发的前瞻性研究。
Aesthetic Plast Surg. 2025 Mar 27. doi: 10.1007/s00266-025-04817-9.
7
Application of platelet-rich plasma lysate combined with hyaluronic acid microneedles for the treatment of alopecia.富血小板血浆裂解物联合透明质酸微针在脱发治疗中的应用。
Drug Deliv Transl Res. 2025 Feb 21. doi: 10.1007/s13346-025-01816-w.
8
Nitric Oxide Donor and Minoxidil Co-Loaded Microneedles Improving Hair Loss Treatment.一氧化氮供体与米诺地尔共载微针改善脱发治疗
Macromol Biosci. 2025 Aug 6:e00225. doi: 10.1002/mabi.202500225.
9
The effectiveness of treatments for androgenetic alopecia: A systematic review and meta-analysis.雄激素性脱发治疗方法的疗效：系统评价和荟萃分析。
J Am Acad Dermatol. 2017 Jul;77(1):136-141.e5. doi: 10.1016/j.jaad.2017.02.054. Epub 2017 Apr 7.
10
Shen-Ying-Yang-Zhen formula promotes angiogenesis around hair follicles, alleviates oxidative stress, and inhibits hair follicle apoptosis through the VEGF/Akt/Caspase-9 signaling axis.申英养真方通过VEGF/Akt/Caspase-9信号轴促进毛囊周围血管生成，减轻氧化应激，并抑制毛囊凋亡。
Phytomedicine. 2025 Jun 15;145:156963. doi: 10.1016/j.phymed.2025.156963.

本文引用的文献

1
Liposomes enhance the hair follicle delivery of minoxidil sulfate with improved treatment of androgenic alopecia.脂质体可增强硫酸米诺地尔向毛囊的递送，从而改善雄激素性脱发的治疗效果。
Int J Pharm. 2025 May 30;677:125642. doi: 10.1016/j.ijpharm.2025.125642. Epub 2025 Apr 24.
2
Immune and Non-immune Interactions in the Pathogenesis of Androgenetic Alopecia.雄激素性脱发发病机制中的免疫与非免疫相互作用
Clin Rev Allergy Immunol. 2025 Mar 1;68(1):22. doi: 10.1007/s12016-025-09034-5.
3
Evaluation of Dutasteride-Loaded Liposomes and Transfersomes for Follicular-Targeting for Androgenic Alopecia Topical Treatment.
用于雄激素性脱发局部治疗的靶向毛囊的载度他雄胺脂质体和传递体的评估。
Pharmaceutics. 2024 Nov 27;16(12):1524. doi: 10.3390/pharmaceutics16121524.
4
Platinum Nanozyme-Loaded Dissolving Microneedles Scavenge ROS and Promote Lineage Progression for Androgenetic Alopecia Treatment.负载铂纳米酶的可溶解微针清除活性氧并促进雄激素性脱发治疗中的谱系进展。
Small Methods. 2025 Apr;9(4):e2401176. doi: 10.1002/smtd.202401176. Epub 2024 Oct 18.
5
A Scoping Review on Complications in Modern Hair Transplantation: More than Just Splitting Hairs.现代毛发移植并发症的范围综述：不仅仅是吹毛求疵
Aesthetic Plast Surg. 2025 Feb;49(3):585-595. doi: 10.1007/s00266-024-04316-3. Epub 2024 Aug 23.
6
Hydrogel forming microneedles loaded with VEGF and Ritlecitinib/polyhydroxyalkanoates nanoparticles for mini-invasive androgenetic alopecia treatment.负载血管内皮生长因子和利特昔替尼/聚羟基脂肪酸酯纳米颗粒的水凝胶形成微针用于微创治疗雄激素性脱发。
Bioact Mater. 2024 Apr 23;38:95-108. doi: 10.1016/j.bioactmat.2024.04.020. eCollection 2024 Aug.
7
Synergistic therapeutic effect of ginsenoside Rg3 modified minoxidil transfersomes (MXD-Rg3@TFs) on androgenic alopecia in C57BL/6 mice.人参皂苷 Rg3 修饰的米诺地尔传递体（MXD-Rg3@TFs）对 C57BL/6 小鼠雄激素性脱发的协同治疗作用。
Int J Pharm. 2024 Apr 10;654:123963. doi: 10.1016/j.ijpharm.2024.123963. Epub 2024 Mar 1.
8
Cardamonin-loaded liposomal formulation for improving percutaneous penetration and follicular delivery for androgenetic alopecia.小豆蔻明脂质体制剂，用于改善雄激素性脱发的经皮渗透和毛囊递送。
Drug Deliv Transl Res. 2024 Sep;14(9):2444-2460. doi: 10.1007/s13346-024-01519-8. Epub 2024 Feb 14.
9
Clinical efficacy and safety of low-dose oral minoxidil versus topical solution in the improvement of androgenetic alopecia: A randomized controlled trial.低剂量口服米诺地尔与外用溶液治疗雄激素性脱发的临床疗效和安全性：一项随机对照试验。
J Cosmet Dermatol. 2024 Mar;23(3):949-957. doi: 10.1111/jocd.16086. Epub 2023 Nov 29.
10
Thermodynamically stable ionic liquid microemulsions pioneer pathways for topical delivery and peptide application.热力学稳定的离子液体微乳液为局部给药和肽的应用开辟了新途径。
Bioact Mater. 2023 Nov 1;32:502-513. doi: 10.1016/j.bioactmat.2023.10.002. eCollection 2024 Feb.