Marinova-Bulgaranova Teodora Vasileva, Hitkova Hristina Yotova, Balgaranov Nikolay Kirilov
Department of Microbiology and Virology, Medical University of Pleven, 5800 Pleven, Bulgaria.
Department of Pediatric Diseases, Medical University of Pleven, 5800 Pleven, Bulgaria.
Microorganisms. 2025 Aug 4;13(8):1819. doi: 10.3390/microorganisms13081819.
is one of the most challenging nosocomial pathogens associated with a variety of hospital infections, such as ventilator-associated pneumonia, wound and urinary tract infections, meningitis, and sepsis, primarily in patients treated in critical care settings. Its classification as a high-priority pathogen is due to the emergence of multidrug-resistant strains in healthcare environments and its tendency to spread clonally. belongs to the - (Acb) complex, a group of genotypically and phenotypically similar species. Differentiating between the species is important because of their distinct clinical significance. However, conventional phenotypic methods, both manual and automated, often fail to provide accurate species-level identification. This review aims to summarize current phenotypic and genotypic methods for the identification of species within the Acb complex, evaluating their strengths and limitations to offer guidance for their appropriate application in diagnostic settings and epidemiological investigations.
是与多种医院感染相关的最具挑战性的医院病原体之一，这些感染包括呼吸机相关性肺炎、伤口和尿路感染、脑膜炎以及败血症，主要发生在重症监护环境中接受治疗的患者身上。它被列为高优先级病原体是由于医疗环境中出现了多重耐药菌株以及其克隆传播的倾向。属于 - （Acb）复合体，这是一组基因型和表型相似的物种。区分这些物种很重要，因为它们具有不同的临床意义。然而，传统的表型方法，无论是手动的还是自动化的，往往无法提供准确的物种水平鉴定。本综述旨在总结目前用于鉴定Acb复合体内物种的表型和基因型方法，评估它们的优势和局限性，以便为其在诊断环境和流行病学调查中的适当应用提供指导。
