Shen Ao, Fan Pan, Fan Dingrong, Wang Yidi, Tang Kailin, Cai Ying, Zhou Hengyu
School of Nursing, Chongqing Medical University, Chongqing, China.
Department of Oncology, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Front Oncol. 2025 Aug 12;15:1572725. doi: 10.3389/fonc.2025.1572725. eCollection 2025.
Chemoradiotherapy is a therapeutic approach that prolongs survival but may simultaneously negatively affect the quality of life (QOL) of cancer patients. Current research on quality of life (QOL) in pan-cancer patients undergoing concurrent chemoradiotherapy (CCRT) lacks systematic integration of bibliometric findings with clinical symptom data.
We retrieved 2762 articles from the Web of Science Core Collections. R-bibliometrix, VOSviewer, and CiteSpace were employed to conduct quantitative analysis and visualize research trends and factors influencing QOL. Complementarily, a cross-sectional study of 117 cervical cancer patients assessed symptom prevalence via CTCAE v5.0, with symptom clusters identified.
The included articles were published between 1995 and 2024. The results revealed that the United States and China had the largest number of publications worldwide. Van Berge Henegouwen was the most productive author. The institution leading in this field was the University of Toronto. The International Journal of Radiation Oncology - Biology - Physics was the most productive journal. In addition, keywords with high burst strengths in recent years were 'open label', 'predictor', and 'preoperative chemoradiotherapy'. Tree-ring map of terms related to QOL was visualized and multiple clusters were found, respectively named as "malnutrition", "watch and wait", and so on. Clusters analyses of specific cancers were performed to reveal these unique differences. Finally, among cervical cancer patients, decreased appetite (79.5%), diarrhea (65.8%), and altered taste (59.0%) were the most prevalent symptoms, with three symptom clusters identified.
More attention was paid to long-term outcome and patient experience during treatment. Through pan-cancer research and in-depth analysis of specific cancers, we have identified various factors affecting QOL in patients undergoing chemoradiotherapy, including treatment methods, treatment-induced symptoms, psychological factors and so on, enabling us to tailor more personalized treatment plans that improve their overall well-being and enhance QOL during and after treatment.
放化疗是一种可延长生存期但可能同时对癌症患者生活质量（QOL）产生负面影响的治疗方法。目前关于接受同步放化疗（CCRT）的泛癌患者生活质量（QOL）的研究缺乏将文献计量学结果与临床症状数据进行系统整合。
我们从科学网核心合集检索了2762篇文章。使用R-bibliometrix、VOSviewer和CiteSpace进行定量分析，并可视化研究趋势和影响生活质量的因素。作为补充，对117例宫颈癌患者进行横断面研究，通过CTCAE v5.0评估症状患病率，并识别症状集群。
纳入的文章发表于1995年至2024年之间。结果显示，美国和中国在全球的出版物数量最多。范·贝赫·赫内古温是产量最高的作者。该领域领先的机构是多伦多大学。《国际放射肿瘤学 - 生物学 - 物理学杂志》是产量最高的期刊。此外，近年来爆发强度较高的关键词是“开放标签”、“预测因子”和“术前放化疗”。绘制了与生活质量相关术语的树状图并发现了多个集群，分别命名为“营养不良”、“观察等待”等。对特定癌症进行了聚类分析以揭示这些独特差异。最后，在宫颈癌患者中，食欲下降（79.5%）、腹泻（65.8%）和味觉改变（59.0%）是最常见的症状，并识别出三个症状集群。
在治疗期间对长期结局和患者体验给予了更多关注。通过泛癌研究和对特定癌症的深入分析，我们确定了影响接受放化疗患者生活质量的各种因素，包括治疗方法、治疗引起的症状、心理因素等，这使我们能够制定更个性化的治疗方案，改善他们的整体健康状况，并提高治疗期间及治疗后的生活质量。
