基于血管紧张素转换酶2的特异性基质：开发与功能分析
Specific Matrix on the Basis of Angiotensin-Converting Enzyme 2: Development and Functional Analysis.
作者信息
Kostin N N, Bobik T V, Rushkevich N Yu, Skryabin G A, Kaliberda E N, Knorre V D, Smirnov I V, Gabibov A G
机构信息
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.
出版信息
Bull Exp Biol Med. 2025 Aug 28. doi: 10.1007/s10517-025-06463-2.
In this study, an affinity matrix based on recombinant human angiotensin-converting enzyme 2 (ACE2) immobilized on a porous polymeric substrate was developed and characterized. The matrix efficiently binds viral particles pseudotyped with the SARS-CoV-2 spike protein. These findings highlight the prospects for creating novel affinity matrices for extracorporeal hemoperfusion aimed at reducing viral load in patients with high viremia and severe COVID-19.
在本研究中，开发并表征了一种基于固定在多孔聚合物基质上的重组人血管紧张素转换酶2（ACE2）的亲和基质。该基质能有效结合以严重急性呼吸综合征冠状病毒2（SARS-CoV-2）刺突蛋白假型化的病毒颗粒。这些发现突出了创建用于体外血液灌流的新型亲和基质的前景，旨在降低病毒血症高和患有严重冠状病毒病2019（COVID-19）患者的病毒载量。
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