Gómez-Trillos Sara, Carrera Pilar, Caballero Amparo, Sheppard Vanessa B, Graves Kristi D, Peshkin Beth N, Schwartz Marc D, Campos Claudia, Garcés Nathaly, Mendoza Alejandra Hurtado de
Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, District of Columbia, USA.
Fisher Center for Hereditary Cancer and Clinical Genomics Research, Washington, District of Columbia, USA.
Psychooncology. 2025 Sep;34(9):e70261. doi: 10.1002/pon.70261.
Culturally targeted narrative education is a promising approach to cancer prevention and control. This study evaluates the uptake of genetic counseling and testing (GCT) in Latinas at risk for hereditary breast and ovarian cancers (HBOC) after watching a culturally targeted narrative video and being navigated to GCT services.
Latina women at increased risk for HBOC were recruited through community-based organizations. Participants responded to surveys before and after watching Spanish-language telenovela-style video. Surveys measured sociodemographic and clinical variables, HBOC and GCT knowledge, transportation with the story, identification with characters, and emotions elicited by the video. After watching video, participants were offered patient navigation services to free or low-cost GCT and completed a 3-month follow-up phone survey to assess GCT uptake.
Participants (N = 40) were 47.35 years old on average (SD = 9.48); all were born outside the United States. At the 3-month follow-up (N = 37), 27 (72.9%) and 26 (70.27%) participants had attended genetic counseling and genetic testing, respectively. U Mann Whitney tests found statistically significant differences between women who attended counseling versus those who did not at baseline knowledge (U = 216.00, p = 0.000) and distress elicited by the video (U = 73.5, p = 0.03). A logistic regression with distress elicited by the video as a predictive variable reached statististical significance (β = -0.27, p = 0.037, CI 95% 0.58-0.98).
GCT uptake was promising, supporting a role for culturally targeted narrative video education along with a patient navigation component in increasing interest in cancer prevention and reducing healthcare disparities in HBOC genetic services.
NCT03075540 (Initial release 2/22/2017).
针对特定文化的叙事教育是癌症预防与控制的一种有前景的方法。本研究评估了有遗传性乳腺癌和卵巢癌（HBOC）风险的拉丁裔女性在观看针对特定文化的叙事视频并获得基因咨询和检测（GCT）服务引导后，对GCT的接受情况。
通过社区组织招募有HBOC高风险的拉丁裔女性。参与者在观看西班牙语肥皂剧风格的视频前后进行调查。调查测量了社会人口统计学和临床变量、HBOC和GCT知识、对故事的理解、对角色的认同以及视频引发的情绪。观看视频后，为参与者提供免费或低成本GCT的患者导航服务，并完成为期3个月的随访电话调查以评估GCT的接受情况。
参与者（N = 40）平均年龄为47.35岁（标准差 = 9.48）；均在美国境外出生。在3个月的随访中（N = 37），分别有27名（72.9%）和26名（70.27%）参与者接受了遗传咨询和基因检测。U曼-惠特尼检验发现，接受咨询的女性与未接受咨询的女性在基线知识（U = 216.00，p = 0.000）和视频引发的困扰方面存在统计学显著差异（U = 73.5，p = 0.03）。以视频引发的困扰作为预测变量的逻辑回归达到统计学显著性（β = -0.27，p = 0.037，95%置信区间0.58 - 0.98）。
GCT的接受情况良好，支持了针对特定文化的叙事视频教育以及患者导航组件在提高癌症预防兴趣和减少HBOC基因服务中的医疗保健差距方面的作用。
NCT03075540（初始发布日期：2017年2月22日）。
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