血清转铁蛋白作为预测突发性感音神经性听力损失预后的潜在标志物：一项前瞻性研究。

Serum transferrin as a potential marker for prediction of prognosis for sudden sensorineural hearing loss: a prospective study.

作者信息

Zhang Silin, Wang Weiping, Huang Xiaowu, Chen Sa, Du Danyi, Chen Yu, Zhang Xiangmin

机构信息

Department of Otolaryngology, Shenzhen Hospital, Southern Medical University, 1333 Xinhu Road, Shenzhen, 518100, Guangdong, China.

出版信息

BMC Neurol. 2025 Aug 29;25(1):367. doi: 10.1186/s12883-025-04387-y.

DOI:10.1186/s12883-025-04387-y

PMID:40883673

Abstract

OBJECTIVE

Clinically significant prognostic indicators have not been identified for sudden sensorineural hearing loss (SSNHL). Consequently, this research aimed to evaluate the effectiveness of iron parameters in predicting prognostic outcomes for patients with SSNHL.

METHODS

Ninety-one individuals with SSNHL were prospectively enrolled and received steroid treatment at a dosage of 1 mg/kg/day for two weeks. Baseline characteristics and iron parameters were collected from participants. Afterward, the pre-and post-treatment hearing of the enrolled patients was compared. The effective group, defined as those with a pure tone audiometry (PTA) improvement of impaired frequencies of ≥ 15 dB or restoration to normal/ unaffected ear levels。.

RESULTS

In the entire cohort, the effective group exhibited a significantly younger age (p = 0.005) and baseline hearing level as well as transferrin saturation (p = 0.036) and higher transferrin levels (p = 0.002) in comparison to the ineffective group. Multivariate analysis identified age (OR, 0.931; 95% CI, 0.889-0.976; p = 0.003), the baseline hearing level (OR, 0.928; 95% CI, 0.894-0.964; p<0.001) and transferrin level (OR, 9.15; 95% CI, 1.838-45.555; p = 0.007) as independent predictors of treatment outcome.

CONCLUSIONS

Higher transferrin levels were associated with an optimal outcome for SSNHL, however further research is needed to understand the mechanisms underlying this effect.

摘要

目的

尚未确定突发性感音神经性听力损失（SSNHL）具有临床意义的预后指标。因此，本研究旨在评估铁参数对预测SSNHL患者预后结果的有效性。

方法

前瞻性纳入91例SSNHL患者，接受剂量为1mg/kg/天的类固醇治疗，持续两周。收集参与者的基线特征和铁参数。之后，比较入选患者治疗前后的听力。有效组定义为纯音听力计（PTA）中受损频率改善≥15dB或恢复到正常/未受影响耳水平的患者。

结果

在整个队列中，与无效组相比，有效组年龄显著更小（p = 0.005），基线听力水平、转铁蛋白饱和度（p = 0.036）及转铁蛋白水平更高（p = 0.002）。多因素分析确定年龄（OR，0.931；95%CI，0.889 - 0.976；p = 0.003）、基线听力水平（OR，0.928；95%CI，0.894 - 0.964；p<0.001）和转铁蛋白水平（OR，9.15；95%CI，1.838 - 45.555；p = 0.007）为治疗结果的独立预测因素。