Girard P F, Trillet M, Confavreux C, Chazot G
Rev Neurol (Paris). 1977 May;133(5):359-62.
The authors present three cases of multiple, intra-cranial meningiomatosis with contact hyperostosis affecting the grandmother, mother and daughter, in a very stereotypic manner. No other sign of von Recklinghausen's disease was noted, except for two tiny neurofibromas on the left hand in the mother. Only the latter suffered from bilateral deafness, but it was not possible to give definite proof of the presence of an acoustic neuroma in this patient. Anatomical verification in the first case, and surgical intervention in the last, confirmed that it was in fact a meningioma. Thus, a new clinical form of expression of neuro-fibromatosis has been found.
作者报告了三例多发性颅内脑膜瘤病伴接触性骨质增生的病例,患者为祖母、母亲和女儿,呈现出非常典型的模式。除母亲左手有两个微小神经纤维瘤外,未发现冯雷克林霍增氏病的其他体征。只有母亲患有双侧耳聋,但无法明确证实该患者存在听神经瘤。第一例进行了解剖验证,最后一例进行了手术干预,证实实际上是脑膜瘤。因此,发现了神经纤维瘤病一种新的临床表型。