糖尿病认知障碍针刺治疗的系统评价与Meta分析：聚焦动物模型
Systematic Review and Meta-Analysis of Acupuncture Treatment for Diabetic Cognitive Impairment: Focus on Animal Models.
作者信息
Jiao Xinyi, Hu Yue, Tian Guoqing
机构信息
Department of Traditional Chinese Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
出版信息
Brain Behav. 2025 Sep;15(9):e70783. doi: 10.1002/brb3.70783.
BACKGROUND
Cognitive impairment is a frequent complication of diabetes, yet effective treatments remain elusive. In animal models, acupuncture has shown potential in improving cognitive deficits related to diabetes, but a comprehensive evaluation of its efficacy is lacking.
MATERIALS AND METHODS
We systematically searched seven databases (PubMed, Web of Science, Embase, OVID, SinoMed, CNKI, and Wanfang) from their inception through January 1, 2025. Studies meeting inclusion criteria underwent quality assessment using the SYRCLE Risk of Bias tool. Data analysis was conducted with Stata 14.0.
RESULTS
Thirteen studies comprising 294 animals were included. Acupuncture significantly reduced blood glucose in diabetic models [SMD = -2.44, 95% CI (-3.33, -1.55); I = 88.9%, p < 0.000], shortened water maze escape latency [SMD = -2.35, 95% CI (-2.86, -1.84); I = 60.0%, p = 0.003], and increased target platform crossings [SMD = 1.49, 95% CI (1.10, 1.88); I = 51.9%, p < 0.001].
CONCLUSION
Acupuncture can improve cognitive impairment in diabetic animal models and lower their blood glucose levels.
背景
认知障碍是糖尿病常见的并发症，但有效的治疗方法仍然难以捉摸。在动物模型中，针灸已显示出改善与糖尿病相关的认知缺陷的潜力，但缺乏对其疗效的全面评估。
材料与方法
我们系统检索了7个数据库（PubMed、Web of Science、Embase、OVID、中国生物医学文献数据库、中国知网和万方数据库），检索时间从各数据库建库至2025年1月1日。符合纳入标准的研究使用SYRCLE偏倚风险工具进行质量评估。数据分析使用Stata 14.0软件。
结果
纳入13项研究，共294只动物。针灸显著降低糖尿病模型的血糖水平[标准化均数差（SMD）=-2.44，95%置信区间（CI）（-3.33，-1.55）；I²=88.9%，p<0.0001]，缩短水迷宫逃避潜伏期[SMD=-2.35，95%CI（-2.86，-1.84）；I²=60.0%，p=0.003]，并增加穿越目标平台的次数[SMD=1.49，95%CI（1.10，1.88）；I²=51.9%，p<0.001]。
结论
针灸可改善糖尿病动物模型的认知障碍并降低其血糖水平。
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