Cheng Hongxin, Zhong Wen, Li Hanbin, Wang Lu, He Chengqi, Huang Liyi, Fu Chenying, Wei Quan
Department of Rehabilitation Medicine Center and Institute of Rehabilitation Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Key Laboratory of Rehabilitation Medicine in Sichuan Province, Chengdu, Sichuan, China.
Mediators Inflamm. 2025 Aug 22;2025:3302911. doi: 10.1155/mi/3302911. eCollection 2025.
With the incidence of cardiovascular disease (CVD) escalating annually, the significance of investigating the correlation between inflammatory markers and lipid-related indices, notably the neutrophil-to-lymphocyte ratio (NLR) and atherogenic index of plasma (AIP), is increasingly paramount. This study aimed to elucidate the distinct and combined roles of NLR and AIP concerning the incidence of CVD. Diagnoses of CVD were established based on self-reported standardized medical condition questionnaires from participants. NLR was computed by dividing the peripheral blood neutrophil count by the lymphocyte count. AIP was calculated as log [triglyceride (TG, mg/dL)/high-density lipoprotein cholesterol (HDL-C, mg/dL)]. The study's primary outcome was the incidence of CVD. To ensure the reliability and accuracy of the results, the analysis incorporated sample weights and complex survey designs. The final analysis included 13,184 individuals. Higher levels of NLR and AIP were independently associated with CVD. After adjusting for all variables, compared to Q1 of AIP or NLR, Q4 of AIP (OR 1.54, 95% CI: 1.19-1.98) and NLR (OR 1.54, 95% CI: 1.19-1.98) was significantly associated with CVD. The joint effects showed that participants with higher levels of NLR and AIP had a significantly higher OR of 1.41(1.06, 1.87). The combination of NLR and AIP has better predictive efficacy (AUC: 0.629) for CVD than alone. This cohort suggests combined effects between the NLR and AIP on CVD. Our findings provide clinical implications for monitoring and managing NLR and AIP levels to mitigate the development of CVD.
随着心血管疾病（CVD）的发病率逐年上升，研究炎症标志物与脂质相关指标之间的相关性，尤其是中性粒细胞与淋巴细胞比值（NLR）和血浆致动脉粥样硬化指数（AIP）的重要性日益凸显。本研究旨在阐明NLR和AIP在CVD发病方面的独特作用及联合作用。CVD的诊断基于参与者自我报告的标准化医疗状况问卷。NLR通过外周血中性粒细胞计数除以淋巴细胞计数计算得出。AIP计算公式为log[甘油三酯（TG，mg/dL）/高密度脂蛋白胆固醇（HDL-C，mg/dL）]。该研究的主要结局是CVD的发病率。为确保结果的可靠性和准确性，分析纳入了样本权重和复杂的调查设计。最终分析包括13184名个体。较高水平的NLR和AIP与CVD独立相关。在对所有变量进行调整后，与AIP或NLR的第一四分位数相比，AIP的第四四分位数（OR 1.54，95%CI：1.19 - 1.98）和NLR的第四四分位数（OR 1.54，95%CI：1.19 - 1.98）与CVD显著相关。联合效应表明，NLR和AIP水平较高的参与者的OR显著更高，为1.41（1.06，1.87）。NLR和AIP的组合对CVD的预测效能（AUC：0.629）优于单独使用。该队列研究表明NLR和AIP对CVD存在联合效应。我们的研究结果为监测和管理NLR和AIP水平以减轻CVD的发展提供了临床启示。
