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超越化疗：探索树姜黄根和纳米羟基磷灰石在神经保护应用中的作用。

Beyond chemotherapy: Exploring tree turmeric root and nano-hydroxyapatite for neuroprotective applications.

作者信息

Li Chuangen, Kaliamoorthy Sriram, Vijayalakshmi Mariappan

机构信息

Department of Rehabilitation Medicine, Ankang People's Hospital, Ankang, 725000, China.

Vinayaka Mission's Medical College and Hospital, Vinayaka Mission's Research Foundation (Deemed to be University), Karaikal, Puducherry, India, 609609.

出版信息

Iran J Basic Med Sci. 2025;28(10):1406-1416. doi: 10.22038/ijbms.2025.84185.18205.

DOI:10.22038/ijbms.2025.84185.18205
PMID:40896697
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12399070/
Abstract

OBJECTIVES

To investigate the physicochemical properties, in vitro efficacy, and in vivo therapeutic potential of novel tree turmeric root and nano-hydroxyapatite (TRE@NHA) composites in mitigating chemotherapy-induced peripheral neuropathy (CIPN).

MATERIALS AND METHODS

TRE@NHA composites were synthesized and characterized using FTIR, XRD, TGA, and HRTEM. In vitro studies using PC12 cells assessed cytotoxicity, anti-inflammatory effects, and neuroprotective properties. An in vivo rat model of CIPN was established using paclitaxel (PTX). Behavioral assessments, histopathological analysis, and oxidative stress markers were evaluated in sciatic nerve tissues.

RESULTS

TRE@NHA composites demonstrated successful integration of TRE into the NHA matrix. In vitro studies revealed significant anti-inflammatory and neuroprotective effects of TRE@NHA-2, particularly in suppressing cytokine production, enhancing cell viability, and mitigating oxidative stress. , TRE@NHA-2 effectively alleviated PTX-induced neuropathic pain, reduced neuronal damage, and exhibited potent antioxidant properties.

CONCLUSION

This study demonstrates the successful development and characterization of novel TRE@NHA composites. The findings strongly suggest that TRE@NHA-2 possesses promising therapeutic potential for mitigating CIPN due to its anti-inflammatory, antioxidant, and neuroprotective properties.

摘要

目的

研究新型树姜黄根与纳米羟基磷灰石（TRE@NHA）复合材料在减轻化疗引起的周围神经病变（CIPN）方面的物理化学性质、体外疗效和体内治疗潜力。

材料与方法

采用傅里叶变换红外光谱（FTIR）、X射线衍射（XRD）、热重分析（TGA）和高分辨率透射电子显微镜（HRTEM）对TRE@NHA复合材料进行合成和表征。使用PC12细胞进行的体外研究评估了细胞毒性、抗炎作用和神经保护特性。使用紫杉醇（PTX）建立CIPN的体内大鼠模型。对坐骨神经组织进行行为评估、组织病理学分析和氧化应激标志物评估。

结果

TRE@NHA复合材料表明TRE成功整合到NHA基质中。体外研究显示TRE@NHA-2具有显著的抗炎和神经保护作用，特别是在抑制细胞因子产生、提高细胞活力和减轻氧化应激方面。此外，TRE@NHA-2有效减轻了PTX诱导的神经性疼痛，减少了神经元损伤，并表现出强大的抗氧化特性。

结论

本研究证明了新型TRE@NHA复合材料的成功开发和表征。研究结果强烈表明，TRE@NHA-2因其抗炎、抗氧化和神经保护特性，在减轻CIPN方面具有广阔的治疗潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3beb/12399070/57a835e1f1c6/IJBMS-28-1406-g011.jpg
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