杀虫氨基甲酸酯类对小鼠脑乙酰胆碱含量、乙酰胆碱酯酶活性及行为的影响。

Effects of insecticidal carbamates on brain acetylcholine content, acetylcholinesterase activity and behavior in mice.

作者信息

Kobayashi H, Yuyama A, Kajita T, Shimura K, Ohkawa T, Satoh K

出版信息

Toxicol Lett. 1985 Dec;29(2-3):153-9. doi: 10.1016/0378-4274(85)90036-0.

Abstract

Mice showed no toxic signs after a single injection of o-sec-butylphenyl methylcarbamate (BPMC, 10 mg/kg) or 2-isopropoxyphenyl-N-methylcarbamate (propoxur, 2 mg/kg). Each dose of BPMC or propoxur caused an increase in acetylcholine content and a decrease in acetylcholinesterase activity in the forebrain of mice at 10 min, followed by an almost complete recovery in the content at 60 min. Spontaneous motor activity was depressed 10 min after and recovered 60 min after, injection of BPMC or propoxur. Neither rotarod performance nor rectal temperature showed any change after injection of BPMC or propoxur. Spontaneous motor activity may therefore be a simple method for assessing small changes in the cholinergic system.

摘要

单次注射邻仲丁基苯基氨基甲酸甲酯（BPMC，10毫克/千克）或2-异丙氧基苯基-N-甲基氨基甲酸酯（残杀威，2毫克/千克）后，小鼠未表现出毒性迹象。每次注射BPMC或残杀威后10分钟，小鼠前脑内乙酰胆碱含量增加，乙酰胆碱酯酶活性降低，随后在60分钟时含量几乎完全恢复。注射BPMC或残杀威后10分钟，自发运动活性受到抑制，60分钟后恢复。注射BPMC或残杀威后，转棒试验表现和直肠温度均未出现任何变化。因此，自发运动活性可能是评估胆碱能系统微小变化的一种简单方法。