循环B细胞和CD4 T细胞的紊乱可将多发性硬化症与其他中枢神经系统自身免疫性疾病区分开来。
Perturbances in Both Circulating B and CD4 T Cells Discriminate Multiple Sclerosis from Other Central Nervous System Autoimmune Diseases.
作者信息
Bogers Laurens, Rip Jasper, Franken Suzanne C, Kuiper Kirsten L, Marques Ana M, Wierenga-Wolf Annet F, Melief Marie-José, Corsten Cato E A, Kranenbarg Romy A M Klein, de Beukelaar Janet, Smets Ide, Wokke Beatrijs H, Titulaer Maarten J, Smolders Joost, van Luijn Marvin M
机构信息
Department of Immunology, MS Center ErasMS, Erasmus University Medical Center, Rotterdam, The Netherlands.
Department of Neurology, Erasmus University Medical Center, Rotterdam, The Netherlands.
出版信息
Eur J Immunol. 2025 Sep;55(9):e70049. doi: 10.1002/eji.70049.
Using spectral flow cytometry, we analyzed circulating lymphocyte subsets in treatment-naive individuals with multiple sclerosis (MS) and other central nervous system autoimmune diseases (CNS AIDs). Elevated B-cell and CD4 T-cell frequencies were a disease-specific feature of MS, while reduced T-bet and CXCR3 B-cell levels were associated with progressive disease.
我们使用光谱流式细胞术分析了未经治疗的多发性硬化症（MS）和其他中枢神经系统自身免疫性疾病（CNS AIDs）患者的循环淋巴细胞亚群。B细胞和CD4 T细胞频率升高是MS的疾病特异性特征，而T-bet和CXCR3 B细胞水平降低与疾病进展相关。
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