Zhou Yanqing, Chen Jialing, Zhu Qin, Lin Binyan
School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China.
School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, China.
Front Pharmacol. 2025 Aug 18;16:1650560. doi: 10.3389/fphar.2025.1650560. eCollection 2025.
Traditional Chinese medicine (TCM) gamboge is a dried resin obtained from Hook f. For over 500 years, TCM gamboge has been used to treat scrofula, carbuncle, jaundice, furuncle, and other chronic and stubborn diseases. An increasing amount of evidence has proven the significant anticancer properties of the main active ingredients from gamboge in recent years. The ingredients of gamboge, such as gambogic acid (GA) and gambogenic acid (GNA), can inhibit tumor growth through various processes, including apoptosis induction, cell cycle arrest, tumor cell invasion and migration inhibition, and autophagy regulation. In this review, we elaborate on the role of the main active ingredients of gamboge in treating cancers. It would be enlightening to provide the possible therapeutic applications of gamboge in the clinic.
中药藤黄是从藤黄科藤黄属植物中获取的一种干燥树脂。500多年来，中药藤黄一直用于治疗瘰疬、痈疽、黄疸、疖肿及其他慢性顽固性疾病。近年来，越来越多的证据证明藤黄主要活性成分具有显著的抗癌特性。藤黄的成分，如藤黄酸（GA）和藤黄新生酸（GNA），可通过多种过程抑制肿瘤生长，包括诱导细胞凋亡、阻滞细胞周期、抑制肿瘤细胞侵袭和迁移以及调节自噬。在本综述中，我们阐述了藤黄主要活性成分在治疗癌症中的作用。提供藤黄在临床上可能的治疗应用将具有启发性。
