克氏锥虫在体外培养时对不同剂型苯硝唑的行为分析：实验见解

Analysis of the Behavior of Trypanosoma cruzi in Culture Against Different Dosage Forms of Benznidazole: Experimental Insights.

作者信息

López-Domínguez Jaime, López-Monteon Aracely, Ochoa-Martínez Paulina, González-García Josue Rafael, Peña-Rodríguez Rodolfo, Waleckx Etienne, Moo-Millán Joel, Ramos-Ligonio Angel

机构信息

LADISER Inmunología y Biología Molecular, Edificio D, Facultad de Ciencias Químicas, Universidad Veracruzana (UV), Prolongación de Oriente 6 #1009, Colonia Rafael Alvarado, C.P. 94340, 86039, Orizaba, Veracruz, Mexico.

Asociacion Chagas con Ciencia y Conocimiento A.C., Orizaba, Veracruz, Mexico.

出版信息

Acta Parasitol. 2025 Sep 3;70(5):189. doi: 10.1007/s11686-025-01125-9.

DOI:10.1007/s11686-025-01125-9

PMID:40903621

Abstract

INTRODUCTION

This study aimed to investigate the influence of benznidazole (BZN) origin on its in vitro potency against various Trypanosoma cruzi strains.

METHODS

Pure BZN, purified BZN, and the pharmaceutical formulation Abarax were evaluated for their activity against several parasite strains.

RESULTS

Results demonstrated significant variability in BZN's effectiveness, contingent upon both its specific form and the T. cruzi strain under investigation. Half-maximal inhibitory concentrations (IC values) exhibited a wide range, indicating that the potency of BZN is not uniform across all its forms or against all parasite strains.

CONCLUSION

In conclusion, this study elucidates the complex interaction between BZN and T. cruzi. The parasite's response to BZN can vary even within a single strain, influenced by the drug's specific presentation. These findings underscore the critical importance of considering both parasite diversity and drug formulation when assessing the efficacy of treatments in laboratory assays.

摘要