Gutierrez Albenda David, Murillo Jiménez Julyana, Rodríguez Varela Laura Natalia, Ulate Blanco Paula, Sánchez Hidalgo Nelson Mauricio
Cyclotron-PET/CT Laboratory, University of Costa Rica, San José, CRI.
School of Medicine, University of Costa Rica, San José, CRI.
Cureus. 2025 Aug 4;17(8):e89326. doi: 10.7759/cureus.89326. eCollection 2025 Aug.
Medullary thyroid carcinoma (MTC) is a rare neuroendocrine tumor with variable clinical presentation, posing both diagnostic and therapeutic challenges. Disease recurrence is common and may manifest solely as elevated tumor markers in the absence of clinical findings or positive morphological imaging. We present the case of a 56-year-old woman diagnosed with MTC in 2011, treated with total thyroidectomy and adjuvant therapy. In 2021, a locoregional recurrence was detected, requiring left-sided neck dissection. During follow-up in 2025, elevated tumor markers were identified despite negative findings on computed tomography (CT). Consequently, an F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT was performed, revealing disease recurrence with multiple lesions suggestive of bone metastases. This case underscores the value of F-FDG PET/CT in the follow-up and detection of MTC recurrence.
甲状腺髓样癌（MTC）是一种罕见的神经内分泌肿瘤，临床表现多样，给诊断和治疗带来挑战。疾病复发很常见，可能仅表现为肿瘤标志物升高，而无临床症状或形态学影像学阳性表现。我们报告一例56岁女性病例，该患者于2011年被诊断为MTC，接受了甲状腺全切除术及辅助治疗。2021年，检测到局部区域复发，需要进行左侧颈部清扫术。在2025年的随访中，尽管计算机断层扫描（CT）结果为阴性，但肿瘤标志物升高。因此，进行了氟脱氧葡萄糖（FDG）正电子发射断层扫描（PET）/CT检查，结果显示疾病复发，有多个提示骨转移的病灶。该病例强调了F-FDG PET/CT在MTC复发随访和检测中的价值。
