Michalik Michael G, Crooke Philip S, Marini John J
Division of Pulmonary, Allergy, Critical Care, and Sleep, University of Minnesota, Minneapolis, MN.
Department of Mathematics, Vanderbilt University, Nashville, TN.
Crit Care Explor. 2025 Sep 5;7(9):e1305. doi: 10.1097/CCE.0000000000001305. eCollection 2025 Sep.
Mean airway pressure, a monitored variable continuously available on the modern ventilator, is the pressure measured at the airway opening averaged over the time needed to complete the entire respiratory cycle. Mean airway pressure is well recognized to connect three key physiologic processes in mechanical ventilation: physical stretch, cardiovascular dynamics, and pulmonary gas exchange. Although other parameters currently employed in adults to determine "safe" ventilation are undoubtedly valuable for daily practice, all have limitations for continuous monitoring of ventilation hazard. The purpose of this communication is to explore the often-underappreciated link between mean airway pressure and the mechanical power (cumulative inflation energy/min) that helps determine the adverse consequences of invasive ventilation (ventilator-induced lung injury).
平均气道压是现代呼吸机上持续可得的一个监测变量，它是在气道开口处测得的压力，在完成整个呼吸周期所需的时间内进行平均。平均气道压在机械通气中连接三个关键生理过程，这一点已得到充分认识：物理性扩张、心血管动力学和肺气体交换。尽管目前在成人中用于确定“安全”通气的其他参数在日常实践中无疑很有价值，但所有这些参数在持续监测通气风险方面都有局限性。本交流的目的是探讨平均气道压与机械功率（累积充气能量/分钟）之间常常被忽视的联系，这种联系有助于确定有创通气（呼吸机诱导的肺损伤）的不良后果。
