Lai Jun, Xiao Xue, Wen Chunyan, Zhang Yaoyu, Meng Wenjun, Zheng Rujun
Department of Biotherapy, Cancer Center, West China Hospital, Sichuan University/West China School of Nursing, Sichuan University, Chengdu, China.
Department of General Surgery, The General Hospital of Western Theater Command, Chengdu, China.
Front Oncol. 2025 Aug 27;15:1656941. doi: 10.3389/fonc.2025.1656941. eCollection 2025.
Peripherally inserted central catheters (PICCs) are widely used for long-term intravenous therapy, especially in cancer patients. Although generally safe, PICC-related complications such as catheter fracture and migration can pose serious risks.
We report a case of a 41-year-old female with lung adenocarcinoma who developed PICC catheter fracture, with the broken segment migrating into the pulmonary artery during chemotherapy. The patient presented without significant symptoms, and imaging confirmed the intravascular migration of the catheter fragment. After multidisciplinary evaluation, the fractured catheter was successfully removed under digital subtraction angiography (DSA) guidance via a minimally invasive endovascular approach. The patient recovered uneventfully.
This case highlights the rare but serious complication of PICC catheter fracture with subsequent migration into the pulmonary artery during chemotherapy in a patient with lung adenocarcinoma. Prompt identification and multidisciplinary management, including minimally invasive retrieval under DSA guidance, ensured a favorable outcome and avoided major morbidity. The experience underscores the importance of standardized PICC maintenance protocols, comprehensive training of nursing staff, and patient education on self-care to minimize preventable complications. Furthermore, our findings emphasize the need for regular catheter monitoring and timely intervention when abnormalities are detected. Minimally invasive endovascular techniques represent a well-documented, safe and effective alternative to traditional surgical methods for the retrieval of intravascular foreign bodies, with advantages of reduced trauma, faster recovery, and fewer complications. Continued efforts to enhance nursing skills, strengthen follow-up, adopt polyurethane catheters instead of silicone PICC per current guidelines, and promote patient awareness are essential to improve the safety and success rates of PICC utilization in cancer populations requiring long-term intravenous access.
经外周静脉穿刺中心静脉导管(PICC)广泛用于长期静脉治疗,尤其是癌症患者。尽管PICC一般较为安全,但诸如导管断裂和移位等与PICC相关的并发症可能带来严重风险。
我们报告一例41岁肺腺癌女性患者,在化疗期间发生PICC导管断裂,断裂段移入肺动脉。患者无明显症状,影像学检查证实导管碎片在血管内移位。经过多学科评估,在数字减影血管造影(DSA)引导下,通过微创血管内方法成功取出断裂导管。患者恢复顺利。
该病例凸显了肺腺癌患者化疗期间罕见但严重的PICC导管断裂并随后移入肺动脉的并发症。及时识别和多学科管理,包括在DSA引导下进行微创取出,确保了良好的预后并避免了严重的发病情况。该经验强调了标准化PICC维护方案、对护理人员进行全面培训以及对患者进行自我护理教育以尽量减少可预防并发症的重要性。此外,我们的研究结果强调了定期导管监测以及在检测到异常时及时干预的必要性。微创血管内技术是一种有充分文献记载的、安全有效的替代传统手术方法来取出血管内异物的方法,具有创伤小、恢复快和并发症少的优点。持续努力提高护理技能、加强随访、按照当前指南采用聚氨酯导管而非硅胶PICC,并提高患者意识,对于提高需要长期静脉通路的癌症患者使用PICC的安全性和成功率至关重要。