One of the major social issues worldwide is tobacco dependency and cigarette smoking (CS) abuse. Given the significant impact of cigarette smoking on human health and diseases, extensive tobacco use and cigarette smoking abuse are certainly a form of drug addiction and should be considered a serious threat to human health. Notably, healthcare spending attributable to cigarette smoking is very high. In this regard, a significant number of biomolecules of natural origin have been described as capable of mitigating the adverse effects of cigarette smoking. In this review, (a) we discuss the impact that the habit of smoking tobacco has on human health and (b) we describe products of natural origin capable of mitigating the effects of cigarette smoke. The conclusion of this review article is that the available information strongly indicates a possible use of the anti-inflammatory aged garlic extract (AGE) and its bioactive components for mitigating the detrimental effects of cigarette smoke on human tissues. The key reasons for proposing this application are that AGE and its key components S-allyl-cysteine and S1-propenyl-cysteine are potent anti-inflammatory agents, bind to Toll-like Receptor-4, inhibit Nuclear Factor-κB, inhibit the expression of pro-inflammatory genes, revert apoptosis induced by cigarette smoke in several cellular model systems and are strong inhibitors of Reactive Oxygen Species (ROS) formation.