He Limei, Yang Jianqi, Wang Shufang, Ma Yicheng, Zou Chenggang
State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan and Key Laboratory of Industrial Microbial Fermentation Engineering of Yunnan Province, School of Life Sciences, Yunnan University, Kunming 650091, China.
Faculty of Health Sciences, University of Macau, Macau 999078, China.
Int J Mol Sci. 2025 Aug 31;26(17):8471. doi: 10.3390/ijms26178471.
Neuromedin U receptors (NMURs) represent a class of evolutionarily conserved G-protein-coupled receptors that play a pivotal role in a variety of physiological processes. However, the role of NMURs in the heat shock response has yet to be elucidated. Using the nematode as a model system, we demonstrate herein that functional loss of NMUR-3 results in reduced survival upon heat shock. The regulation of thermal tolerance by NMUR-3 is dependent on AMPK. Furthermore, our data demonstrate that NMUR-3 activates autophagy via AMPK, thereby contributing to protection against heat shock. The results of this study suggest that NMUR-3 is crucial for thermal tolerance in .
神经介素U受体（NMURs）是一类进化上保守的G蛋白偶联受体，在多种生理过程中起关键作用。然而，NMURs在热休克反应中的作用尚未阐明。我们以线虫为模型系统，在此证明NMUR-3的功能丧失会导致热休克后存活率降低。NMUR-3对热耐受性的调节依赖于AMPK。此外，我们的数据表明，NMUR-3通过AMPK激活自噬，从而有助于抵御热休克。本研究结果表明，NMUR-3对线虫的热耐受性至关重要。
Zotero 插件
