Gieszinger Gábor, Kui Balázs, Hegyi Péter, Hegyi Péter Jenő, Vincze Áron, Erőss Bálint, Szentesi Andrea, Vass Vivien, Abonyi-Tóth Zsolt, Izbéki Ferenc, Illés Anita, Szabó Imre, Czimmer József, Németh Balázs Csaba, Gajdán László, Papp Mária, Hamvas József, Czakó László
Department of Internal Medicine, Center for Gastroenterology, Albert Szent-Györgyi Medical School, University of Szeged, 6725 Szeged, Hungary.
Centre for Translational Medicine, Semmelweis University, 1094 Budapest, Hungary.
J Clin Med. 2025 Sep 6;14(17):6304. doi: 10.3390/jcm14176304.
: Hypercalcemia is a rare etiology of acute pancreatitis; only a few cases have been reported in the literature, and the severity of hypercalcemia-induced AP is unknown. We aimed to assess the occurrence and severity of hypercalcemia-induced AP and compare it with the clinical characteristics of AP caused by other etiological factors. : We collected data from patients from the Hungarian Acute Pancreatitis Registry who had AP, a serum calcium level above 2.6 mmol/L, and no other AP etiology. AP patients with etiologies other than hypercalcemia served as control. : A total of 1.20% of our AP patients (16/1328) had a clear hypercalcemic etiology, 5.05% (67/1328) had a mixed etiology, and 1245 patients were in the control group. Severe AP, organ failure, and renal failure were significantly more common in patients with hypercalcemia-induced AP than in the control or the mixed etiology groups. Heart failure was significantly more frequent in the clear hypercalcemia-induced group than in patients with normal serum calcium AP. Respiratory failure was significantly more common in the clear hypercalcemia-induced AP group than in the mixed etiology-induced group. There was no significant difference in other analyzed parameters. The outcome of AP was not associated with the severity of hypercalcemia within the hypercalcemic group. : Compared with AP of different etiologies, hypercalcemia-induced AP is more likely to develop into severe AP and organ failure (heart and kidneys).
高钙血症是急性胰腺炎的一种罕见病因；文献中仅报道了少数病例，且高钙血症所致急性胰腺炎的严重程度尚不清楚。我们旨在评估高钙血症所致急性胰腺炎的发生率和严重程度，并将其与其他病因引起的急性胰腺炎的临床特征进行比较。：我们从匈牙利急性胰腺炎登记处收集了患有急性胰腺炎、血清钙水平高于2.6 mmol/L且无其他急性胰腺炎病因的患者的数据。非高钙血症病因的急性胰腺炎患者作为对照。：我们的急性胰腺炎患者中，共有1.20%（16/1328）有明确的高钙血症病因，5.05%（67/1328）有混合病因，1245例患者在对照组。高钙血症所致急性胰腺炎患者中，重症急性胰腺炎、器官衰竭和肾衰竭明显比对照组或混合病因组更常见。明确的高钙血症所致组中心力衰竭明显比血清钙正常的急性胰腺炎患者更频繁。明确的高钙血症所致急性胰腺炎组中呼吸衰竭明显比混合病因所致组更常见。其他分析参数无显著差异。高钙血症组内急性胰腺炎的结局与高钙血症的严重程度无关。：与不同病因的急性胰腺炎相比，高钙血症所致急性胰腺炎更易发展为重症急性胰腺炎和器官衰竭（心脏和肾脏）。
