Wu Chaoran, Wang Xinyu, Cai Yunfeng, Zhang Jialu, Li Haipeng, Wang Wenbing, Yang Yun, Zhang Ren, Cai Yue, Li Xiaoyi, Ouyang Huan, Wang Changhui
Department of Cardiology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui, China.
Department of Vascular and Thyroid Surgery, Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui, China.
ACS Omega. 2025 Aug 26;10(35):40379-40391. doi: 10.1021/acsomega.5c05687. eCollection 2025 Sep 9.
ST-segment elevation myocardial infarction (STEMI) represents the most severe clinical manifestation of coronary heart disease. Despite the availability of current treatments, their high cost and surgical complexity have limited their effectiveness in reducing the associated high rates of disability and mortality. Additionally, conventional nanoparticles face significant challenges in achieving precise and controlled drug release within the infarcted myocardium. In this study, we developed a carbon monoxide (CO)-releasing system based on rhodium nanodots. The resulting nanoparticles (Rh-PEG-CO NDs) enable site-specific CO release from infarcted cardiac tissue upon ultrasound stimulation. The combination of CO and rhodium nanodots effectively scavenges reactive oxygen species (ROS) and mitigates postinfarction myocardial fibrosis, thereby attenuating the inflammatory response in the infarcted region. Both in vitro and in vivo experiments demonstrated that these functional nanoparticles exhibit high efficacy in inhibiting cardiomyocyte apoptosis, reversing pathological cardiac remodeling, and improving overall cardiac function. This study presents a novel CO-releasing platform that advances the clinical potential of CO-based therapies and underscores the promise of metal-based nanomaterials in biomedical applications.
ST段抬高型心肌梗死（STEMI）是冠心病最严重的临床表现。尽管现有治疗方法可用，但其高成本和手术复杂性限制了它们在降低相关高致残率和死亡率方面的有效性。此外，传统纳米颗粒在梗死心肌内实现精确和可控药物释放方面面临重大挑战。在本研究中，我们开发了一种基于铑纳米点的一氧化碳（CO）释放系统。所得纳米颗粒（Rh-PEG-CO NDs）在超声刺激下能够从梗死心脏组织中实现位点特异性CO释放。CO与铑纳米点的组合有效清除活性氧（ROS）并减轻梗死后心肌纤维化，从而减轻梗死区域的炎症反应。体外和体内实验均表明，这些功能性纳米颗粒在抑制心肌细胞凋亡、逆转病理性心脏重塑和改善整体心脏功能方面具有高效性。本研究提出了一种新型的CO释放平台，提升了基于CO疗法的临床潜力，并强调了金属基纳米材料在生物医学应用中的前景。
