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乙醇给药期间脑内儿茶酚胺，纳洛酮对脑多巴胺和去甲肾上腺素对乙醇戒断反应的影响。

Brain catecholamines during ethanol administration, effect of naloxone on brain dopamine and norepinephrine responses to withdrawal from ethanol.

作者信息

Guaza C, Borrell S

出版信息

Pharmacol Res Commun. 1985 Dec;17(12):1159-67. doi: 10.1016/0031-6989(85)90028-1.

DOI:10.1016/0031-6989(85)90028-1
PMID:4095124
Abstract

The variations in brain dopamine (DA) and norepinephrine (NE) levels after ethanol administration have been studied in rats. Acute ethanol administration significantly decreased brain DA and NE levels. After chronic ethanol intake no changes were observed in brain catecholamines. Ethanol withdrawal induced significant decreases in DA and NE concentrations in the brain. The administration of naloxone, antagonist of opiate receptors, blocked the effects of ethanol deprivation on brain catecholamines. These data suggest that endogenous opioids may be involved in the ethanol-withdrawal syndrome.

摘要

在大鼠中研究了给予乙醇后脑内多巴胺（DA）和去甲肾上腺素（NE）水平的变化。急性给予乙醇显著降低脑内DA和NE水平。长期摄入乙醇后，脑内儿茶酚胺未观察到变化。乙醇戒断导致脑内DA和NE浓度显著降低。给予阿片受体拮抗剂纳洛酮可阻断乙醇戒断对脑内儿茶酚胺的影响。这些数据表明内源性阿片类物质可能参与乙醇戒断综合征。

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