Czaja J A, Butera P C
Physiol Behav. 1985 Dec;35(6):873-7. doi: 10.1016/0031-9384(85)90253-7.
Female rats which had been ovariectomized either 7 days earlier (short-term deprivation, N = 11) or 35 days earlier (long-term deprivation, N = 11) were tested for their response to treatments of estradiol benzoate (6.0 micrograms/kg body weight) and progesterone (1.2 mg/kg). The long-term deprived females showed less sexual behavior than females deprived for only 7 days prior to treatment. In particular, lordosis quotients after treatment with estradiol alone were significantly lower in the long-term deprived females, t(20) = 3.194, p less than 0.01. Following a supplemental progesterone injection, the lordosis scores and the number of proceptive behaviors displayed by long-term deprived females were also significantly lower than these measures in short-term deprived females, t(20) = 3.481, p less than 0.01 and t(20) = 3.737, p less than 0.01, respectively. In contrast, the two groups did not differ in the degree to which estradiol treatment suppressed food intake, F(1,20) = 2.306, N.S. Likewise, the changes in water intake and body weight produced by estradiol treatment did not differ significantly between the two groups, F(1,20) = 0.118, N.S. and F(1,20) = 0.452, N.S., respectively. The results obtained from the sex behavior tests are generally consistent with the notion that hormonal deprivation alters the responsivity or sensitivity of female rats to estradiol. However, these changes do not appear to involve a general decline in receptor sensitivity or number, because the ability of estradiol to suppress ingestive behaviors was not diminished in the long-term deprived females.
对7天前（短期剥夺，N = 11）或35天前（长期剥夺，N = 11）进行卵巢切除的雌性大鼠，测试它们对苯甲酸雌二醇（6.0微克/千克体重）和孕酮（1.2毫克/千克）治疗的反应。长期剥夺的雌性大鼠表现出的性行为比治疗前仅剥夺7天的雌性大鼠少。特别是，长期剥夺的雌性大鼠单独用雌二醇治疗后的脊柱前凸商显著更低，t(20) = 3.194，p < 0.01。在补充注射孕酮后，长期剥夺的雌性大鼠的脊柱前凸评分和表现出的接受行为数量也显著低于短期剥夺的雌性大鼠，t(20) = 3.481，p < 0.01和t(20) = 3.737，p < 0.01。相比之下，两组在雌二醇治疗抑制食物摄入的程度上没有差异，F(1,20) = 2.306，无统计学意义。同样，雌二醇治疗引起的两组水摄入量和体重变化也没有显著差异，F(1,20) = 0.118，无统计学意义和F(1,20) = 0.452，无统计学意义。性行为测试的结果总体上与激素剥夺会改变雌性大鼠对雌二醇的反应性或敏感性这一观点一致。然而，这些变化似乎并不涉及受体敏感性或数量的普遍下降，因为长期剥夺的雌性大鼠中雌二醇抑制摄食行为的能力并未减弱。
