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[炎症渗出物诱导细胞分裂过程中培养巨噬细胞染色质凝聚的改变]

[Modification of chromatin condensation in cultured macrophages during induction of cell division by an inflammatory exudate].

作者信息

Ronot X, Blondelon D, Adolphe M, Fontagné J, Rouveix B, Lechat P

出版信息

C R Acad Hebd Seances Acad Sci D. 1977 Jul 4;285(1):101-3.

PMID:409539
Abstract

The determination of chromatin condensation in rat peritoneal macrophages in culture showed a predominance of heterochromatin with low transcriptory activity. After induction of division in rat peritoneal macrophages in culture by an acute inflammatory exudate, a decrease of heterochromatin and an increase of euchromatin were observed. This result brings further evidence to support previous observations according to which this type of exudate shows mitogenic properties.

摘要

对培养的大鼠腹膜巨噬细胞中染色质凝聚的测定显示,异染色质占优势,转录活性较低。在用急性炎性渗出物诱导培养的大鼠腹膜巨噬细胞分裂后,观察到异染色质减少,常染色质增加。这一结果为支持先前的观察提供了进一步的证据,即这种类型的渗出物具有促有丝分裂特性。

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