Lehmann H D
Arzneimittelforschung. 1985;35(12):1795-801.
The interaction of gallopamil (Procorum) and propranolol was studied in conscious trained dogs by injecting gallopamil intravenously (consecutive injection of 0.0464, 0.1 and 0.215 mg/kg at 30-min intervals) with and without propranolol pre-medication (0.464 mg/kg i.v., 10 min before the first injection of gallopamil). An intraindividual comparison of the cardiovascular effects was made. The interaction was mostly minor and occurred only with the highest dose of gallopamil. It was noticeable most in the influence on myocardial contractility which was more pronounced than the influence on electrophysiological parameters. A shift in threshold doses was not observed. Much more pronounced effects of the gallopamil-propranolol interaction become apparent when the animals were at the same time subjected to vagal blockade (methylatropine). In this situation, combined administration of gallopamil and propranolol led to a greater reduction of contractility, increase of AV block and occurrence of asystole. As regards the latter, a shift in the threshold dose occurred. The differences in the intensity of the interaction between gallopamil and propranolol in animals with or without vagal blockade are therefore a consequence of the presence or absence of reflex regulation. The findings explain, and relativize, the clear-cut interaction in the anaesthetized dog demonstrated by other authors, i.e. experimental conditions matching an autonomic blockade.
通过静脉注射加洛帕米（普罗卡胺）（以30分钟的间隔连续注射0.0464、0.1和0.215mg/kg），在有或没有普萘洛尔预处理（静脉注射0.464mg/kg，在第一次注射加洛帕米前10分钟）的情况下，对清醒的训练犬进行了加洛帕米（普罗卡胺）与普萘洛尔相互作用的研究。进行了个体内心血管效应的比较。相互作用大多较小，仅在加洛帕米的最高剂量时出现。在对心肌收缩力的影响方面最为明显，比对电生理参数的影响更显著。未观察到阈剂量的变化。当动物同时接受迷走神经阻滞（甲基阿托品）时，加洛帕米-普萘洛尔相互作用的影响更为明显。在这种情况下，加洛帕米和普萘洛尔联合给药导致收缩力更大程度降低、房室传导阻滞增加和心脏停搏的发生。就后者而言，阈剂量发生了变化。因此，有或没有迷走神经阻滞的动物中加洛帕米和普萘洛尔之间相互作用强度的差异是反射调节存在或不存在的结果。这些发现解释并相对化了其他作者在麻醉犬中所证明的明显相互作用，即与自主神经阻滞相匹配的实验条件。
