表儿茶素、常山酮和吡格列酮可延长雄性而非雌性遗传异质性小鼠的寿命。
Extension of lifespan by epicatechin, halofuginone and mitoglitazone in male but not female genetically heterogeneous mice.
作者信息
Strong Randy, Nelson James F, Bogue Molly A, Colca Jerry R, Denzel Martin, Diaz Vivian, Finck Brian N, Gladyshev Vadim N, Horvath Steve, Jiang Nisi, Keller Tracy, Kletzien Rolf F, Korstanje Ron, Kumar Navasuja, Leeuwenburgh Christiaan, Fernandez Elizabeth, Galecki Andrzej, Ginsburg Brett, Han Melissa, Kaczorowski Catherine, Leiser Scott, Lopez-Cruzan Marisa, Raj Ken, Reifsnyder Peter C, Rosenthal Nadia A, Rosi Susanna, Shindyapina Anastasia, Stacpoole Peter, Salmon Adam B, Tyshkovskiy Alexander, Walter Peter, Whitman Malcolm, Miller Richard A, Harrison David E
机构信息
Geriatric Research, Education and Clinical Center and Research Service, Department of Pharmacology, Barshop Institute for Longevity and Aging Studies, South Texas Veterans Health Care System, The University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, USA.
Department of Cellular and Integrative Physiology and Barshop Institute for Longevity and Aging Studies, The University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, USA.
出版信息
Geroscience. 2025 Sep 19. doi: 10.1007/s11357-025-01881-6.
Mice bred in 2021 were tested by the Interventions Testing Program (ITP) for possible lifespan benefits of 2BAct (2BA), dichloroacetate (DCA), Epicatechin (EPI), Forskolin (FSK), Halofuginone (HAL) and Mitoglitazone (MIT). All agents were administered in the diet ad libitum beginning at 7 months of age. In male mice, EPI increased median lifespan by ~ 5%, and HAL and MIT each increased median lifespan by ~ 9%. EPI and HAL, but not MIT, increased 90% survival. In addition to adding 3 new agents to the list of interventions identified by the ITP that extend lifespan, this report continues the strong male bias in the efficacy of life-extending drugs identified so far.
2021年培育的小鼠由干预测试项目（ITP）进行测试，以探究2BAct（2BA）、二氯乙酸（DCA）、表儿茶素（EPI）、福斯高林（FSK）、卤夫酮（HAL）和吡格列酮（MIT）对寿命可能产生的益处。所有药物均从7月龄开始随意添加到饮食中。在雄性小鼠中，EPI使中位寿命延长了约5%，HAL和MIT各自使中位寿命延长了约9%。EPI和HAL提高了90%的生存率，但MIT没有。除了在ITP确定的延长寿命的干预措施列表中增加3种新药物外，本报告延续了迄今为止已确定的延长寿命药物疗效中存在的明显的雄性偏向。
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