Huo Wenying, Qiao Yingying, Li Enkai, Li Mengyun, Che Long
College of Animal Science and Technology, Henan University of Animal Husbandry and Economy, Zhengzhou, China.
Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, United States.
Front Vet Sci. 2025 Sep 8;12:1680448. doi: 10.3389/fvets.2025.1680448. eCollection 2025.
Rotavirus (RV) remains a leading cause of severe gastroenteritis in infants and young animals worldwide, contributing to significant morbidity and mortality despite the availability of vaccines. The gastrointestinal tract's health, shaped by complex interactions between nutrition, the gut microbiota, and the host immune system, plays a crucial role in RV pathogenesis and outcomes. Emerging evidence suggests that dietary components not only influence the composition and function of the gut microbiota but also modulate immune responses essential for protection against RV. This review integrates findings from human and animal models to elucidate the interplay between nutrition, microbiota, and immunity in the context of RV infection. We aim to shed light on the mechanisms by which dietary factors and microbial communities influence RV susceptibility and severity, and how this knowledge could guide the development of more effective preventive and therapeutic strategies.
轮状病毒（RV）仍然是全球婴幼儿和幼龄动物严重胃肠炎的主要病因，尽管有疫苗可用，但仍导致大量发病和死亡。胃肠道健康由营养、肠道微生物群和宿主免疫系统之间的复杂相互作用所塑造，在RV发病机制和疾病转归中起关键作用。新出现的证据表明，饮食成分不仅影响肠道微生物群的组成和功能，还能调节对RV感染的保护至关重要的免疫反应。本综述整合了来自人类和动物模型的研究结果，以阐明在RV感染背景下营养、微生物群和免疫之间的相互作用。我们旨在揭示饮食因素和微生物群落影响RV易感性和严重程度的机制，以及这些知识如何能够指导开发更有效的预防和治疗策略。
