梦境回忆不佳与阿尔茨海默病生物标志物及痴呆风险相关。
Poor dream recall associates with Alzheimer's disease biomarkers and dementia risk.
作者信息
Lipnicki Darren M, Valentí Meritxell, Valeriano-Lorenzo Elizabeth, Vella Ashleigh S, Zea-Sevilla María Ascensión, Ricciardi Mario, Frades Belén, Martinez Minerva, Wagner Sonia, Sachdev Perminder S, Del Ser Teodoro, Sanchez-Juan Pascual
机构信息
Centre for Healthy Brain Ageing (CHeBA), UNSW Sydney, Sydney, NSW 2052, Australia.
Alzheimer's Center Reina Sofia - CIEN Foundation, 28031 Madrid, Spain.
出版信息
medRxiv. 2025 Sep 17:2025.09.16.25335946. doi: 10.1101/2025.09.16.25335946.
INTRODUCTION
Dreaming is subserved by the default mode network (DMN) and can be abolished by focal lesions within key regions. DMN dysfunction is promoted by pre-clinical Alzheimer's pathology and apolipoprotein E () ε4 carriage, but any effects of these on dreaming are unknown.
METHODS
Associations between dream recall and ε4 carriage and blood phosphorylated tau (p-tau) 217 levels were determined using data for 1049 cognitively normal adults. Associations between dream recall and cognitive decline and dementia risk were also investigated.
RESULTS
Higher p-tau217 levels and ε4 carriage were both associated with lower chances of dream recall, independently of memory test scores and other covariates. Not recalling dreams at baseline was associated with faster cognitive decline and greater likelihood of dementia over 10 years of follow up.
DISCUSSION
Poor dream recall in later life may be a novel and easily assessed indicator of early neurodegeneration.
引言
做梦由默认模式网络（DMN）维持，关键区域的局灶性病变可消除做梦。临床前阿尔茨海默病病理学和载脂蛋白E（）ε4携带会促进DMN功能障碍，但这些对做梦的任何影响尚不清楚。
方法
使用1049名认知正常成年人的数据，确定梦的回忆与ε4携带和血液磷酸化tau（p-tau）217水平之间的关联。还研究了梦的回忆与认知衰退和痴呆风险之间的关联。
结果
较高的p-tau217水平和ε4携带均与梦的回忆几率较低相关，与记忆测试分数和其他协变量无关。在基线时不回忆梦与随访10年期间更快的认知衰退和更高的痴呆可能性相关。
讨论
晚年梦的回忆不佳可能是早期神经退行性变的一个新的且易于评估的指标。
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