Moscoso Uribe Freya, Riond Barbara, Del Chicca Francesca, Ruetten Maja, Grimm Felix, Liesegang Annette, Kook Peter H
Institute of Animal Nutrition and Dietetics, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland.
Clinical Laboratory, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland.
J Feline Med Surg. 2025 Sep;27(9):1098612X251367621. doi: 10.1177/1098612X251367621. Epub 2025 Sep 28.
ObjectivesThe aim of the present study was to describe the course of lipase activity, pancreatic lipase immunoreactivity (PLI) and clinical findings over time in cats.MethodsFour clinically healthy cats and two diarrhoeic cats from a research colony aged 2-8 years with normal haematology and serum biochemistry results were followed up with lipase measurements over a total of 12 months in this descriptive study. Lipase activity (LIPCRoche; reference interval [RI] 8-26 U/l) was determined at day 0, and lipase activity and concurrent PLI (Spec fPL; RI 0-4.4 µg/l) were determined at days 19, 47, 54, 221 and 369. All cats were examined weekly. The pancreas and gastrointestinal tract of all cats were examined via ultrasonography.ResultsLipase activity and PLI in four clinically healthy cats was in the range of 10-283 U/l (median 69) and 1.2-86 µg/l (median 13), respectively. Lipase activity and PLI in two cats with enteropathy was in the range of 16-130 U/l (median 42) and 1.9-36 µg/l (median 8.3). The magnitude and nature of change were always the same for both assays. The correlation between assays was very high ( 0.984; <0.0001). The pancreas was normal on ultrasound in both diarrhoeic cats and two healthy cats, whereas a hypoechoic and enlarged pancreas was found in two clinically healthy cats with persistently increased lipase values. All cats had ultrasonographic evidence of enteropathy. No pattern could be recognised in the temporal lipase progression; only one healthy cat with an ultrasonographically abnormal pancreas had continuously increasing values. Both cats with large bowel diarrhoea were diet-responsive.Conclusions and relevanceLipase activity and PLI varied from normal to markedly increased in clinically healthy cats and cats with diet-responsive enteropathy and a normal pancreas on ultrasonography. Both lipase assays yielded virtually identical results. No apparent association between lipase results and clinical or ultrasonographic findings was found. The results illustrate the difficulties clinicians face when trying to assess the significance of lipase levels in cats.
目的
本研究的目的是描述猫体内脂肪酶活性、胰腺脂肪酶免疫反应性（PLI）随时间的变化过程以及临床症状。
方法
在这项描述性研究中，对4只临床健康的猫和2只腹泻猫进行了为期12个月的随访，这些猫来自一个研究群体，年龄在2至8岁之间，血液学和血清生化检查结果正常。在第0天测定脂肪酶活性（LIPCRoche；参考区间[RI]8 - 26 U/l），并在第19、47、54、221和369天测定脂肪酶活性及同时测定PLI（Spec fPL；RI 0 - 4.4 μg/l）。每周对所有猫进行检查。通过超声检查所有猫的胰腺和胃肠道。
结果
4只临床健康猫的脂肪酶活性和PLI分别在10 - 283 U/l（中位数69）和1.2 - 86 μg/l（中位数13）范围内。2只患有肠病的猫的脂肪酶活性和PLI分别在16 - 130 U/l（中位数42）和1.9 - 36 μg/l（中位数8.3）范围内。两种检测方法的变化幅度和性质始终相同。两种检测方法之间的相关性非常高（r = 0.984；P < 0.0001）。在两只腹泻猫和两只健康猫中，超声检查显示胰腺正常，而在两只临床健康但脂肪酶值持续升高的猫中，发现胰腺低回声且肿大。所有猫均有超声检查证据显示存在肠病。在脂肪酶随时间的变化过程中未发现规律；只有一只胰腺超声检查异常的健康猫的脂肪酶值持续升高。两只患有大肠腹泻的猫对饮食有反应。
结论及意义
在临床健康的猫以及患有饮食反应性肠病且超声检查胰腺正常的猫中，脂肪酶活性和PLI从正常到显著升高不等。两种脂肪酶检测方法得出的结果几乎相同。未发现脂肪酶结果与临床或超声检查结果之间存在明显关联。这些结果说明了临床医生在评估猫脂肪酶水平的意义时所面临的困难。
