Li Xuanling, You Min, Zhang Xiaoyun, Wei Jingjing, Lin Guangyao, Tang Qianjue, Xu Lianwei
Department of Gynecology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Department of Pathology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Front Oncol. 2025 Sep 12;15:1504231. doi: 10.3389/fonc.2025.1504231. eCollection 2025.
Mixed ovarian malignant germ cell tumors (MOGCTs) are rare neoplasms composed of two or more malignant germ cell components, representing less than 1% of all ovarian germ cell tumors. They primarily affect adolescents and young women, presenting a clinical challenge due to their histologic heterogeneity, potential for recurrence, and the need to balance oncologic safety with fertility preservation.
We reported a 22-year-old woman diagnosed with a four-component MOGCT in the right ovary-comprising yolk sac tumor, immature teratoma, embryonal carcinoma, and dysgerminoma-along with a dysgerminoma component in the left ovary. Considering her age and fertility desire, fertility-sparing surgery was performed, followed by adjuvant BEP chemotherapy. At 12-month follow-up, the patient remained disease-free with regular menstruation and no signs of recurrence.
This case highlights the feasibility of fertility-sparing treatment in patients with complex bilateral MOGCTs. Given the rarity and histological diversity of such tumors, individualized treatment planning, strict staging, and long-term surveillance are essential to optimize clinical outcomes and preserve reproductive potential.
混合性卵巢恶性生殖细胞肿瘤（MOGCTs）是由两种或更多种恶性生殖细胞成分组成的罕见肿瘤，占所有卵巢生殖细胞肿瘤的比例不到1%。它们主要影响青少年和年轻女性，由于其组织学异质性、复发可能性以及在肿瘤安全性与生育力保留之间取得平衡的必要性，带来了临床挑战。
我们报告了一名22岁女性，其右侧卵巢被诊断为包含卵黄囊瘤、未成熟畸胎瘤、胚胎癌和无性细胞瘤的四成分MOGCT，同时左侧卵巢有一个无性细胞瘤成分。考虑到她的年龄和生育意愿，实施了保留生育功能的手术，随后进行了辅助性BEP化疗。在12个月的随访中，患者疾病无复发，月经规律，无复发迹象。
该病例突出了对复杂双侧MOGCT患者进行保留生育功能治疗的可行性。鉴于此类肿瘤的罕见性和组织学多样性，个体化的治疗计划、严格的分期以及长期监测对于优化临床结局和保留生殖潜能至关重要。
