孕中期子宫动脉多普勒在巴哈马高危居民先兆子痫和胎儿生长受限早期预测中的作用

Role of second trimester uterine artery doppler in early prediction of preeclampsia and intrauterine growth restriction among high-risk Bahamian residents.

作者信息

Clare Azaria, Sakharkar Vrunda

机构信息

The University of the West Indies School of Clinical Medicine and Research, Nassau, The Bahamas.

出版信息

SAGE Open Med. 2025 Sep 28;13:20503121251378109. doi: 10.1177/20503121251378109. eCollection 2025.

DOI:10.1177/20503121251378109

PMID:41031173

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12477355/

Abstract

BACKGROUND

Uterine artery doppler velocimetry has proven to be efficient in the prediction of preeclampsia and intrauterine growth restriction. We aimed to determine its value among high-risk Bahamian women and the most predictive parameter.

METHODS

We prospectively observed 128 women to detect the frequency of preeclampsia and intrauterine growth restriction development in relation to uterine artery doppler velocimetry. The main outcome measures were resistance index, pulsatility index and notching.

RESULTS

The mean difference of 0.082 (±0.011; 95% CI: -0.096, -0.069) in the resistance index and 0.122 (±0.011; 95% CI: -0.144, -0.100) in the pulsatility index between those without preeclampsia and those with, was statistically significant ( < 0.001). The mean RI had a better prognostic value than the mean pulsatility index (OR: 2.623E+51 (95% CI: 2.577E+25, 2.671E+77); < 0.001. Notching showed a statistically significant with the development of intrauterine growth restriction.

CONCLUSION

The best predictor of preeclampsia was the Resistance Index indices, while end diastolic notching was the best predictor for intrauterine growth restriction.

摘要

背景

子宫动脉多普勒测速已被证明在预测先兆子痫和胎儿宫内生长受限方面是有效的。我们旨在确定其在巴哈马高危女性中的价值以及最具预测性的参数。

方法

我们前瞻性地观察了128名女性，以检测与子宫动脉多普勒测速相关的先兆子痫和胎儿宫内生长受限的发生频率。主要观察指标为阻力指数、搏动指数和切迹。

结果

未患先兆子痫者与患先兆子痫者之间，阻力指数的平均差异为0.082（±0.011；95%可信区间：-0.096，-0.069），搏动指数的平均差异为0.122（±0.011；95%可信区间：-0.144，-0.100），差异具有统计学意义（<0.001）。平均阻力指数比平均搏动指数具有更好的预后价值（比值比：2.623E+51（95%可信区间：2.577E+25，2.671E+77）；<0.001）。切迹与胎儿宫内生长受限的发生具有统计学意义。