Hook W A, Snyderman R, Mergenhagen S E
Infect Immun. 1972 Jun;5(6):909-14. doi: 10.1128/iai.5.6.909-914.1972.
Upon incubation of hamster serum with bacterial endotoxin, a factor is produced which releases histamine and heparin from hamster mast cells and increases capillary permeability in guinea pig skin. The major histamine-releasing activity derived from hamster serum was characterized by gel filtration, found to have a molecular weight of approximately 60,000, and shown by electrophoresis to migrate with alpha-2- or beta-1-globulins. The ability to increase vascular permeability was not reversed by antihistamine. On the basis of these properties, the histamine-liberating factor generated by endotoxin in hamster serum differed significantly from known anaphylatoxins.
将仓鼠血清与细菌内毒素一起孵育后，会产生一种因子，该因子可从仓鼠肥大细胞中释放组胺和肝素，并增加豚鼠皮肤的毛细血管通透性。通过凝胶过滤对源自仓鼠血清的主要组胺释放活性进行了表征，发现其分子量约为60,000，并且通过电泳显示其与α-2或β-1球蛋白一起迁移。抗组胺药不能逆转增加血管通透性的能力。基于这些特性，内毒素在仓鼠血清中产生的组胺释放因子与已知的过敏毒素有显著差异。
