Esteban M M, OJeda Casas J A, Laso Borrego M T, Marcos C P
Acta Allergol. 1977 Dec;32(6):413-25. doi: 10.1111/j.1398-9995.1977.tb01365.x.
The effect of DSCG olution per os was studied in four infants with immediate hypersensitivity reaction to cow's milk and egg, manifested by digestive and cutaneous symptoms. Previous administration of a 1 per cent DSCG solution by mouth resulted in diminution of both the digestive and cutaneous symptoms associated with allergen challenge. The best time interval between oral DSCG and the allergen challenge was about 30 min. The drug lost effectiveness when the solution was prepared more than a week in advance of its administration. A 2-year follow-up in two of the patients revealed the reappearance of cutaneous and digestive symptoms and, for the first time, the onset of wheezing while continuing to administer the allergens and despite continuous oral DSCG. The characteristics of these cases raise questions about the means of sensitization, and the possible mechanism of action of oral DSCG in the inhibition of non-digestive symptoms. Clinical indications for its use are discussed.
对4名对牛奶和鸡蛋有速发型过敏反应、表现为消化和皮肤症状的婴儿，研究了口服色甘酸钠溶液的效果。先前口服1%色甘酸钠溶液可减轻与过敏原激发相关的消化和皮肤症状。口服色甘酸钠与过敏原激发之间的最佳时间间隔约为30分钟。当溶液在给药前一周以上配制时，药物失去效力。对其中2名患者进行的2年随访显示，在继续给予过敏原且持续口服色甘酸钠的情况下，皮肤和消化症状再次出现，并且首次出现喘息。这些病例的特征引发了关于致敏方式以及口服色甘酸钠抑制非消化症状的可能作用机制的问题。讨论了其临床应用指征。
