用假单胞菌脂多糖处理的动物的“免疫”RNA介导的抗菌免疫转移。
Transfer of antibacterial immunity by "Immune" RNA from animals treated with pseudomonas lipopolysaccharide.
作者信息
Barasoain I, Rojo J M, Portolés A
出版信息
Z Immunitatsforsch Immunobiol. 1978;154(1):34-40.
PMID:414470
Abstract
The humoral primary immune response to Pseudomonas aeruginosa lipopolysaccharide was studied. Mice immunized with various doses of LPS developed anti-LPS antibodies. Antibody activity was due to 19S and 7S immunoglobulins. Extracts rich in RNA from spleen cells of immune mice were able to transfer specific anti-LPS response to normal recipients. Immunogenic antigen contamination of RNA was ruled out by a variety of controls.
摘要
对铜绿假单胞菌脂多糖的体液初次免疫反应进行了研究。用不同剂量脂多糖免疫的小鼠产生了抗脂多糖抗体。抗体活性归因于19S和7S免疫球蛋白。来自免疫小鼠脾细胞的富含RNA的提取物能够将特异性抗脂多糖反应转移给正常受体。通过多种对照排除了RNA的免疫原性抗原污染。
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