Laks J, Pilon R N, Klovekorn W P, Anderson W, MacCallum J R, O'Connor N E
Ann Surg. 1974 Jul;180(1):103-9. doi: 10.1097/00000658-197407000-00016.
The effects of acute normovolemic hemodilution on hemodynamics, oxygen transport, tissue perfusion and blood volume were studied. The subjects were four patients undergoing total hip replacement with prebleeding and hemodilution under fluoroxene and nitrous oxide anesthesia. The hematocrit was reduced to 29% and 21% by bleeding in two steps with simultaneous infusion of plasmanate and lactated Ringer's solution. The major compensation was a rise in CO to 123% and 136%. Systemic oxygen transport (COX arterial O(2) content) was only slightly reduced and the arteriovenous oxygen difference decreased. Tissue perfusion remained excellent. Blood volume was slightly expanded. The procedure was well tolerated by this group of selected patients, and homologous blood utilization was markedly reduced.
研究了急性等容血液稀释对血流动力学、氧运输、组织灌注和血容量的影响。受试者为4例在氟烷和氧化亚氮麻醉下进行全髋关节置换术的患者，术前采血并进行血液稀释。分两步放血，同时输注血浆和乳酸林格氏液，使血细胞比容分别降至29%和21%。主要的代偿机制是心输出量增加至123%和136%。全身氧运输（心输出量×动脉血氧含量）仅略有降低，动静脉氧差减小。组织灌注保持良好。血容量略有增加。这组经过挑选的患者对该操作耐受性良好，异体血的使用明显减少。
