Fiser R H, Denniston J C, McGann V G, Kaplan J, Alder W H, Kastello M D, Beisel W R
Infect Immun. 1973 Jul;8(1):105-9. doi: 10.1128/iai.8.1.105-109.1973.
Humoral and cellular immune responses to several antigens were compared in control and hypercholesterolemic groups of monkeys. Chronic hypercholesterolemia, with concomitant hyperphospholipidemia and hypotriglyceridemia, was produced experimentally by feeding monkeys a high-fat, high-cholesterol diet. When studied prior to infection, hypercholesterolemic monkeys exhibited impaired development of precipitating antibodies against ovalbumin, enhanced sensitivity to tuberculin antigen (stimulated apparently by mycobacterial components in complete Freund adjuvant), and an increased rate of clearance of colloidal carbon from blood. During pneumococcal infection the ability of neutrophiles from hypercholesterolemic monkeys to reduce nitroblue tetrazolium dye showed an increase greater than that of control monkeys; both groups exhibited increased but comparable final clearance rates of colloidal carbon, although the increment of increase was smaller in hypercholesterolemic monkeys.
在对照组和高胆固醇血症的猴子组中，比较了对几种抗原的体液免疫和细胞免疫反应。通过给猴子喂食高脂肪、高胆固醇饮食，实验性地产生了伴有高磷脂血症和低甘油三酯血症的慢性高胆固醇血症。在感染前进行研究时，高胆固醇血症的猴子表现出针对卵清蛋白的沉淀抗体发育受损、对结核菌素抗原的敏感性增强（显然由完全弗氏佐剂中的分枝杆菌成分刺激）以及从血液中清除胶体碳的速率增加。在肺炎球菌感染期间，高胆固醇血症猴子的中性粒细胞还原硝基蓝四氮唑染料的能力显示出比对照猴子更大的增加；两组的胶体碳最终清除率均增加，但具有可比性，尽管高胆固醇血症猴子的增加幅度较小。
