Eggen D A
J Lipid Res. 1974 Mar;15(2):139-45.
The metabolism of cholesterol was studied in baboons, rhesus monkeys, and squirrel monkeys while they were being fed either a low fat, low cholesterol (basal) diet or the basal diet supplemented with saturated fat and cholesterol (atherogenic diet). When the diet was changed from basal to atherogenic, the mean total serum cholesterol concentration increased from 70 to 180 mg/dl in the baboon, from 168 to 283 mg/dl in the squirrel monkey, and from 144 to 608 mg/dl in the rhesus monkey. In animals fed the atherogenic diet, the percentage of dietary cholesterol absorbed was greatest in the rhesus monkey and least in the baboon. The fraction of the total body pool of cholesterol that was derived from the diet was greatest in the squirrel monkey and least in the baboon. The turnover of the body pool of cholesterol was several times faster in the squirrel monkey than in the baboon or the rhesus monkey when either dict was fed. The mean total fecal excretion of endogenous cholesterol and bile acid increased in all species on transition to the atherogenic diet; however, the relative contributions of the neutral and acidic fractions to the increase in total excretion differed among species. The difference in percentage of dietary cholesterol absorbed may, in part, account for the large differences in serum cholesterol during the atherogenic diet period. Comparison with other published results indicates that of these species cholesterol metabolism in the baboon is most like that in the human.
在狒狒、恒河猴和松鼠猴进食低脂、低胆固醇（基础）饮食或补充了饱和脂肪和胆固醇的基础饮食（致动脉粥样化饮食）时，对它们的胆固醇代谢进行了研究。当饮食从基础饮食改为致动脉粥样化饮食时，狒狒的平均总血清胆固醇浓度从70毫克/分升升至180毫克/分升，松鼠猴从168毫克/分升升至283毫克/分升，恒河猴从144毫克/分升升至608毫克/分升。在喂食致动脉粥样化饮食的动物中，恒河猴吸收的膳食胆固醇百分比最高，狒狒最低。来自饮食的胆固醇占全身胆固醇池的比例在松鼠猴中最大，在狒狒中最小。无论喂食哪种饮食，松鼠猴体内胆固醇池的周转率都比狒狒或恒河猴快几倍。在所有物种向致动脉粥样化饮食转变时，内源性胆固醇和胆汁酸的平均总粪便排泄量均增加；然而，中性和酸性部分对总排泄量增加的相对贡献在不同物种间有所不同。膳食胆固醇吸收百分比的差异可能部分解释了致动脉粥样化饮食期间血清胆固醇的巨大差异。与其他已发表结果的比较表明，在这些物种中，狒狒的胆固醇代谢最接近人类。
