Dishon T, Rosenmann E, Sela J, Ulmansky M, Boss J H
Immunology. 1974 Jan;26(1):145-53.
Acute sialoadenitis, ascribed to local formation of immune complexes, develops in sensitized rats after a single intraductal challenge with the sensitizing antigen. Multiple intraductal challenges induce a state of non-reactivity of the organ characterized by a lack of inflammatory reaction to the sensitizing antigen. This non-reactivity is antigen-specific, since introduction of ovalbumin, after multiple intraductal instillations of bovine serum albumin (BSA), elicits an inflammatory response in animals immunized with the two antigens. At the same time, instillation of BSA into the contralateral gland, which has not been challenged, causes acute adenitis. Anti-BSA antibodies are detected in the serum and parotid saliva at the time of refractoriness of the gland. The phenomenon is a transient one since the faculty of the salivary gland to respond by an inflammatory reaction recovers after a challenge-free period. These experiments bring to light a new phenomenon, the possible mechanisms of which are discussed.
急性涎腺炎归因于免疫复合物的局部形成，在致敏大鼠经导管内单次注射致敏抗原后发生。多次经导管内注射会诱导器官进入一种无反应状态，其特征是对致敏抗原缺乏炎症反应。这种无反应是抗原特异性的，因为在用牛血清白蛋白（BSA）多次经导管内滴注后再引入卵清蛋白，会在同时用这两种抗原免疫的动物中引发炎症反应。与此同时，将BSA滴注到未受刺激的对侧腺体中会引起急性腺炎。在腺体出现不应性时，血清和腮腺唾液中可检测到抗BSA抗体。该现象是短暂的，因为在一段无刺激期后，唾液腺通过炎症反应作出反应的能力会恢复。这些实验揭示了一种新现象，并对其可能的机制进行了讨论。
