二硫苏糖醇对兔结肠和豚鼠回肠组胺受体的影响。

Effect of dithiothreitol on histamine receptors in rabbit colon and guinea-pig ileum.

Glover W E

Clin Exp Pharmacol Physiol. 1979 Mar-Apr;6(2):151-7. doi: 10.1111/j.1440-1681.1979.tb00019.x.

Abstract

Dithiothreitol, an agent which reduces disulphide linkages to sulphydryl groups, potentiated the contractile responses of the rabbit colon and guinea-pig ileum to histamine, but had no effect on the resting tone or on the responses of these preparations to acetylcholine. 2. The potentiation was greater than that produced by antagonism of histamine's weak inhibitory action by metiamide, and still occurred after blockade of H2-receptors with metiamide; it is concluded that DTT potentiates responses to stimulation of H1-receptors in both preparations. 3. In this respect, these H1-receptors resemble those in vascular smooth muscle in the rabbit but not in the guinea-pig; it is concluded that there is a tissue variation rather than a species variation in the response of H1-receptors in the rabbit and guinea-pig to DTT.

摘要

二硫苏糖醇能将二硫键还原为巯基，它可增强兔结肠和豚鼠回肠对组胺的收缩反应，但对静息张力以及这些标本对乙酰胆碱的反应没有影响。2. 这种增强作用比用甲硫咪特拮抗组胺的微弱抑制作用所产生的增强作用更大，在用甲硫咪特阻断H2受体后这种增强作用仍然存在；由此得出结论，二硫苏糖醇增强了这两种标本对H1受体刺激的反应。3. 在这方面，这些H1受体类似于兔血管平滑肌中的H1受体，而不像豚鼠血管平滑肌中的H1受体；由此得出结论，兔和豚鼠H1受体对二硫苏糖醇的反应存在组织差异而非种属差异。