Herreman F, Brun P, Cannet G, Savin E, Vannier D
Arch Mal Coeur Vaiss. 1974 Oct;67(10):1157-67.
A study of the left ventricular function based on the haemodynamic data combined with those provided by biplane cineangiography was performed in 35 cases with left ventricular volume overload (20 cases of mitral incompetence and 15 of aortic insufficiency). The importance of the haemodynamic changes and of the adaptation mechanisms set up were described. The more intense dilatation-hypertrophy of aortic incompetence than of mitral incompetence plays an essential part. The role of Starling's mechanism is underlined. Estimation of the contractile value of the myocardium, taken into account the mechanical overload and the conditions of late-diastolic lengthening of the fibre and of impedance to left ventricular ejection was determined. An obvious myocardial failure, demonstrated in approximately one third of the cases, by determination of some contractility indices estimated in the ejection phase, Vf sigma max in particular, the only one valid in the presence of valvular regurgitation. In the other cases, the moderate decrease of myocardial contractility was masked by compensatory mechanisms.
对35例左心室容量超负荷患者(20例二尖瓣关闭不全和15例主动脉瓣关闭不全)进行了一项基于血流动力学数据并结合双平面心血管造影提供的数据的左心室功能研究。描述了血流动力学变化和所建立的适应机制的重要性。主动脉瓣关闭不全比二尖瓣关闭不全更强烈的扩张-肥厚起着至关重要的作用。强调了斯塔林机制的作用。考虑到机械负荷以及纤维舒张末期延长和左心室射血阻抗的条件,确定了心肌收缩值的估计值。通过测定射血期估计的一些收缩性指标,特别是Vf sigma max(在存在瓣膜反流时唯一有效的指标),在大约三分之一的病例中显示出明显的心肌衰竭。在其他病例中,心肌收缩性的中度降低被代偿机制所掩盖。