Leis D, Clarin A
Geburtshilfe Frauenheilkd. 1979 Jan;39(1):54-7.
Ten women who took oral contraceptives for six months or longer were investigated. The women took in a randomized sequence cyproteronazetate 2 mg. ethinyloestradiol 50 mcg. (Diane), D-Norgestrel 0.25 mg., ethinyloestradiol 50 mcg. (Neogynon), and Lynestrenol 2.5 mg. with ethinyloestradiol 50 mcg. (Lyndiol). During each treatment cycle at four defined pounts the sebaceous secretions from the skin of the forehead was measured. Since each patient received one cycle of each of the oral contraceptives each patient served as her own control. With Diane and Neogynon the sebaceous secretions were the same. With ingestion of Lyndiol there was a significantly higher sebaceous secretion than with the other two oral contraceptives (p less than 0.05, t-test for paired observations).
对10名服用口服避孕药6个月或更长时间的女性进行了调查。这些女性以随机顺序服用环丙孕酮醋酸酯2毫克、炔雌醇50微克(达英),左炔诺孕酮0.25毫克、炔雌醇50微克(诺孕丸),以及炔雌醇50微克的利奈孕酮2.5毫克(琳迪欧)。在每个治疗周期的四个特定时间点,测量前额皮肤的皮脂分泌量。由于每位患者都接受了每种口服避孕药的一个周期治疗,所以每位患者都作为自己的对照。服用达英和诺孕丸时,皮脂分泌量相同。服用琳迪欧后,皮脂分泌量明显高于其他两种口服避孕药(p<0.05,配对观察t检验)。