人宫颈癌DNA分布与细胞分化的相关性

Correlation of DNA distribution and cytological differentiation of human cervical carcinomas.

作者信息

Jakobsen A, Bichel P, Sell A

出版信息

Virchows Arch B Cell Pathol Incl Mol Pathol. 1979;31(1):75-9. doi: 10.1007/BF02889925.

Abstract

The DNA distribution of biopsy specimens from 46 patients suffering from cervical carcinoma was analysed by flow cytometry and compared with the cytological differentiation. According to morphological criteria the carcinomas were classified as highly differentiated, moderately differentiated and poorly differentiated. The results demonstrate that highly differentiated tumours contain hyperploid cells predominantly with hyperdiploid DNA content. Hyperploid cell populations in the moderately differentiated tumours are mainly in the hyperdiploid and tetraploid regions. Poorly differentiated tumours contain hypertetraploid and aneuploid cell populations. The significance of these findings is discussed.

摘要

通过流式细胞术分析了46例宫颈癌患者活检标本的DNA分布，并与细胞分化程度进行了比较。根据形态学标准，将癌分为高分化、中分化和低分化。结果表明，高分化肿瘤主要含有超二倍体DNA含量的超倍体细胞。中分化肿瘤中的超倍体细胞群主要位于超二倍体和四倍体区域。低分化肿瘤含有超四倍体和非整倍体细胞群。讨论了这些发现的意义。